Calcium Carbonate

Selected References:

  • Altuwaijri M. 2022. Evidence-based treatment recommendations for gastroesophageal reflux disease during pregnancy: A review. Medicine101(35).
  • Anderka M, et al, and the National Birth Defects Prevention Study. 2012. Medications Used to Treat Nausea and Vomiting of Pregnancy and the Risk of Selected Birth Defects. Birth Defects Res (Part A); 94:22-30.
  • Beinder E. 2007. Calcium-supplementation in pregnancy-is it a must?. Ther Umsch. 2007 May;64(5):243-7.
  • Borkenhagen JF, et al. 2013. Neonatal hypocalcemic seizures due to excessive maternal calcium ingestion. Pediatr Neurol. 48(6):469-71.
  • D’Souza R, et al. 2013. Calcium carbonate intoxication in pregnancy: the return of the milk-alkali syndrome. J Obstet Gynaecol Can. 35(11): 976–7.
  • Fairney A, Weir AA. 1970. The effect of abnormal maternal plasma calcium levels on the offspring of rats. J Endocr 48:337-345.
  • Hofmeyr GJ, et al. 2014. Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary. BJOG: 121(8): 951–957.
  • Ito M, et al. 1994. Prevention of preeclampsia with calcium supplementation and vitamin D3 in an antenatal protocol. Int J Gynaecol Obstet 47(2):115- 120.
  • Heinonen OP, et al. 1977 Birth Defects and Drugs in Pregnancy. Littleton, Mass.: John Wright-PSG, pp 444, 479, 498.
  • Katz PO, et al. 2022. ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. Am J Gastroenterol. 117(1):27-56.
  • Kolnick L, et al. 2011. Hypercalcemia in pregnancy: a case of milk-alkali syndrome. J Gen Intern Med. 26(8):939-42.
  • Lagarto A, et al. 2013. Prenatal effects of natural calcium supplement on Wistar rats during organogenesis period of pregnancy. Exp Toxicol Pathol. 65(1-2):49-53.
  • Merialdi M, et al. 2003. Nutritional interventions during pregnancy for the prevention or treatment of impaired fetal growth: an overview of randomized controlled trials. J Nutr 133(5 Suppl 2):1626S-1631S.
  • Morton A. 2002. Milk-alkali syndrome in pregnancy, associated with elevated levels of parathyroid hormone-related protein. Intern Med J 32: 492-494.
  • National Institutes of Health Office of Dietary Supplements. 2022. Calcium Fact Sheet for Health Professionals. Available at: https://ods.od.nih.gov/factsheets/Calcium-HealthProfessional/.
  • Picolos MK, et al. 2004. Milk-alkali syndrome in pregnancy. Obstet Gynecol 104:1201-4.
  • Thornton MD, et al. 2013. Neonatal seizures: soothing a burning topic. Pediatr Emerg Care. 29(10):1107-10.
  • Trezevant MS, 2019. Hypercalcemia-induced pancreatitis in pregnancy following calcium carbonate ingestion. J Pharm Pract. 32(2):225–7.
  • Robertson W. 2002. Calcium carbonate consumption during pregnancy: an unusual cause of neonatal hypocalcemia. Journal of child neurology. 17(11):853-55.
  • Rodriguez H. 2018. Are You Getting Enough Calcium to Get Pregnant?. Natural Fertility Info: 1.
  • Ulliam ME, Linas SL. 1988. The milk-alkali syndrome in pregnancy. Case report. Miner Electrolyte Metab 14:208-10


Calcium Carbonate

Selected References:   

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  • Allweiler SI, Kogan LR. 2013. Inhalation anesthetics and the reproductive risk associated with occupational exposure among women working in veterinary anesthesia. Vet Anaesth Analg, 40(3):285-289. 
  • Anderson PO. 2021. General anesthesia while breastfeeding. Breastfeeding Medicine, 16(4):275-277.  
  • Andropoulos DB, Greene MF. 2017. Anesthesia and developing brains – Implications of the FDA Warning. N Engl J Med, 376(10):905-907.  
  • Beatriz L, et al. 2015. Anesthesia for non-obstetrical surgery during pregnancy. Gen Med Open Access; 3:1–4.  
  • Bleeser T, et al. 2022. Neurodevelopmental outcomes after prenatal exposure to anaesthesia for maternal surgery: a propensity-score weighted bidirectional cohort study. Anaesthesia, 78:159–169. 
  • Brodsky JB, et al. 1980. Surgery during pregnancy and fetal outcome. Am J Ob Gyn, 138(8):1165-1167. 
  • Choi HN, et al. 2021. Evaluation of safety and foeto-maternal outcome following non-obstetric surgery in pregnancy: a retrospective single-site Australian study. ANZ J Surg, 91:627-632.  
  • Cusimano MC, et al. 2023. Adverse fetal outcomes and maternal mortality following nonobstetric abdominopelvic surgery in pregnancy: a systematic review and meta-analysis. Ann Surg, 278:e147–e157. 
  • Czeizel AE, et al. 1998. Reproductive outcome after exposure to surgery under anesthesia during pregnancy. Arch Gynecol Obstet, 261(4):193-199. 
  • Dalal PG, et al. 2014. Safety of the breast-feeding infant after maternal anesthesia. Paediatr Anaesth, (4):359-371.  
  • Duncan PG, et al. 1986. Fetal risk of anesthesia and surgery during pregnancy. Anesthesiology, 64:790-794.  
  • Fisher SC, et al. 2020. Maternal surgery and anesthesia during pregnancy and risk of birth defects in the National Birth Defects Prevention Study, 1997-2011. Birth Defects Res, 112(2):162-174.  
  • Gwanzura C, et al. 2023. Effect of anesthesia administration method on apgar scores of infants born to women undergoing elective cesarean section. BMC Anesthesiol. 23(1):142. 
  • Haataja, A, et al. 2023. Non-obstetric surgery during pregnancy and the effects on maternal and fetal outcomes: A systematic review. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, 112(3), 187–205. 
  • Ing C, et al. 2021. Prenatal exposure to general anesthesia and childhood behavioral deficit. Anesth Analg. 133(3):595-605. 
  • Jankowsky J, et al. 2023. Best Practices for the Care of Breastfeeding Patients Requiring Local or General Anesthesia. Nurs Womens Health. 27(3):231-236. 
  • Knill-Jones RP, et al. 1975. Anaesthetic practice and pregnancy. Lancet, 2:807–809. 
  • Mazze RI, Källén B. 1989. Reproductive outcome after anesthesia and operation during pregnancy: a registry study of 5405 cases. Am J Obstet Gynecol, 161(5):1178-1185. 
  • Olutoye OA, et al. 2018. Food and Drug Administration warning on anesthesia and brain development: implications for obstetric and fetal surgery. Am J Obstet Gynecol, 218(1):98-102. 
  • Robbins LS, et al. 2021. General anesthesia for cesarean delivery and childhood neurodevelopment and perinatal outcomes: a secondary analysis of a randomized controlled trial. Int J Obstet Anesth. 45:44-40. 
  • Sanders RD, et al. 2013. Impact of anaesthetics and surgery on neurodevelopment: an update. Br J Anaesth, 110 Suppl 1:i53-72.  
  • Smith BE. 1963. Fetal prognosis after anesthesia during gestation. Anesth Analg, 42;521-526. 
  • Shnider SM, Webster, GM. 1965. Maternal and fetal hazards of surgery during pregnancy. Am J Obstet Gynecol, 92;891-900. 
  • Sylvester GC, et al. 1994. First-trimester anesthesia exposure and the risk of central nervous system defects: a population-based case-control study. Am J Public Health, 84(11)1757-1760. 
  • Tolcher MC, et al. 2018. Nonobstetric surgery during pregnancy. Obstet Gynecol 132:395–403.  
  • Upadya M, Saneesh P. 2016. Anaesthesia for non-obstetric surgery during pregnancy. Indian J Anaesth 60:234.   
  • US FDA. FDA Drug Safety Communication. 4/27/17. FDA review results in new warnings about using general anesthetics and sedation drugs in young children and pregnant women. Update. FDA approves label changes for use of general anesthetic and sedation drugs in young women. https://www.fda.gov/Drugs/DrugSafety/ucm532356.htm  
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Calcium Carbonate

Selected References

  • Bird TM, et al. 2009. Demographic and environmental risk factors for gastroschisis and omphalocele in the National Birth Defects Prevention Study. J Ped Surg, 44(8):1546-1551.  
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  • BanihaniSA. 2019. Effect of ibuprofen on semen quality. Andrologia: 51(4):e13228. 
  • Brandlistuen RE et al. 2013. Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled study. Int J Epidemiol, 42(6):1702-1713.  
  • Choi E-Y, et al. 2023. Neonatal and maternal adverse outcomes and exposure to nonsteroidal anti-inflammatory drugs during early pregnancy in South Korea: a nationwide cohort study. PLoS Med, 20(2):e1004183.  
  • Dawood MY. 1993. Nonsteroidal antiinflammatory drugs and reproduction. Am J Obstet Gynecol, 169(5):1255-1265.  
  • Daniel S, et al. 2014. Fetal exposure to nonsteroidal anti-inflammatory drugs and spontaneous abortion. Can Med Assoc J 186(5):E177-E182. 
  • Daniel S, et al. 2015. NSAIDs and spontaneous abortions – true effect or an indication bias? Br J Clin Pharmacol, 80(4):750-754. 
  • Dathe K, et al. 2018. No evidence of adverse pregnancy outcome after exposure to ibuprofen in the first trimester—Evaluation of the national Embryotox cohort. Reproductive Toxicology, 79: 32-38. 
  • Ericson A and Kallen BA. 2001. Nonsteroidal anti-inflammatory drugs in early pregnancy. Reprod Toxicol, 15:371- 375.  
  • Esposito DB, et al. 2021. Periconceptional nonsteroidal anti-inflammatory drug use, folic acid intake, and the risk of spina bifida. Birth Defects Res, 113(17):1257-1266.  
  • Halpern JA, et al. 2020. Effects of nonsteroidal anti-inflammatory drug (NSAID) use upon male gonadal function: A national, population-based study. Fertil Steril; 113(3):469–476. 
  • Hernandez RK, et al. 2012; Nonsteroidal anti-inflammatory drug use among women and the risk of birth defects. Am J Obstet Gynecol, 206:228.e1-e8.  
  • Høyer BB, et al. 2017. Use of non-prescription analgesics and male reproductive function. Reprod Toxicol; 74:70–7. 
  • Kavoussi PK, et al. 2018. Ibuprofen does not have an adverse impact on semen parameters. J Assist Reprod Genet 35(12):2201-2204. 
  • Killick S and Elstein M. 1987. Pharmacological production of luteinized unruptured follicles by prostaglandin synthetase inhibitors. Fertil Steril, 47:773-777. 
  • Kristensen DM, et al. 2018. Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism. Proc Natl Acad Sci U S A, 115(4):E715-E724.  
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  • Nakhai-Pour HR et al. 2011. Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion. CMAJv 183(15):1713-1720.  
  • Nezvalova-Henriksen K et al. 2013. Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective study. BJOG, 120(8):948-959.  
  • Nielsen GL, et al. 2001. Risk of adverse birth outcome and miscarriage in pregnant users of non-steroidal anti-inflammatory drugs: population based observational study and case-control study. BMJ, 322(7281):266-270.  
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Calcium Carbonate

Selected References:

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  • Akison LK, et al. 2019. Adverse health outcomes in offspring associated with fetal alcohol exposure: a systematic review of clinical and preclinical studies with a focus on metabolic and body composition outcomes. Alcohol Clin Exp Res 43(7):1324-1343. 
  • Akison LK, et al. 2019. Adverse reproductive outcomes associated with fetal alcohol exposure: a systematic review. Reprod Camb Engl. 157(4):329-343. 
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  • Carter RC, et al. 2022. Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort. Am J Clin Nutr 4;116(2):460-469.  
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  • Coles, CD, et al.  2024.  Prenatal alcohol exposure and health at midlife: self-reported health outcomes in two cohorts.  Alcohol: Clin Exp Res, 48 (11), 2045-2059, doi.org/10.1111/acer.15441 
  • de Angelis C, et al. 2020. Smoke, alcohol and drug addiction and female fertility. Reprod Biol Endocrinol RBE. 18:21  
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  • Eisenberg, M.L, et al. (2024). Preconception alcohol consumption in both partners and risk of miscarriage. Reproductive BioMedicine Online, 104698. 
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Calcium Carbonate

Selected References:  

  • Althagafi H, et al. 2022. Effect of hidradenitis suppurativa on obstetric and neonatal outcomes. J Matern Fetal Neonatal Med; 35(25):8388-8393.  
  • Chellappan B, et al. 2022. Dermatologic Management of Hidradenitis Suppurativa and Impact on Pregnancy and Breastfeeding. Cutis; 109(3):160-162.   
  • Collier E, et al. 2020. Special considerations for women with hidradenitis suppurativa. Int J Womens Dermatol; 6(2):85-88.  
  • Fitzpatrick L, et al. 2022. Adverse pregnancy and maternal outcomes in women with hidradenitis suppurativa. J Am Acad Dermatol; 86(1):46-54. 
  • Li K, et al. 2024. Hidradenitis Suppurativa and Maternal and Offspring Outcomes. JAMA Dermatol. 160(12):1297-1303.  
  • Lotan P, et al. 2023. Association between Hidradenitis Suppurativa and Abnormalities in Semen Parameters and Sexual Function: A Pilot Study. Acta Derm Venereol; 103:adv11603.  
  • Lyons AB, et al. 2020. Evaluation of Hidradenitis Suppurativa Disease Course During Pregnancy and Postpartum. JAMA Dermatol; 156(6):681-685. 
  • Lyons AB, et al. 2020. Retrospective cohort study of pregnancy outcomes in hidradenitis suppurativa. Br J Dermatol; 183(5):945-947.   
  • Oumeish OY, Al-Fouzan AW. 2006. Miscellaneous diseases affected by pregnancy. Clin Dermatol; 24(2):113-7.  
  • Özbek L, et al. 2025. Hidradenitis Suppurativa Treatment During Pregnancy and Lactation: Navigating Challenges. Int J Dermatol; 64(7):1173-1185. 
  • Prens LM, et al. 2021. Hidradenitis suppurativa disease course during pregnancy and postpartum: a retrospective survey study. Br J Dermatol; 185(5):1072-1074. 
  • Sakya SM, et al. 2022. Outcomes of pregnancy and childbirth in women with hidradenitis suppurativa. J Am Acad Dermatol; 86(1):61-67. 
  • Seivright JR, et al. 2022. Impact of Pregnancy on Hidradenitis Suppurativa Disease Course: A Systematic Review and Meta-Analysis. Dermatology; 238(2):260-266. 
  • Tzur Bitan D, et al. 2021. The association between hidradenitis suppurativa and male and female infertility: A population-based study. Australas J Dermatol; 62(2):e223-e227. 
  • Vossen AR, et al. 2017. Menses and pregnancy affect symptoms in hidradenitis suppurativa: A cross-sectional study. J Am Acad Dermatol; 76(1):155-156.  
  • Walsh DP. 2025. Pregnancy Outcomes in Hidradenitis Suppurativa Patients. AMIA Annu Symp Proc; 2024:1169-1175.