Triazolam (Halcion®)

Selected References:

  • Arango O, et al. 1996. Reversible azoospermia in a patient treated with triazolam. Eur J Contracept Reprod Health Care; 1:293-4.
  • Bagger NT, et al. 2023. Perinatal outcomes after therapeutic rest in the latent phase of labor: A cohort study. Acta obstetricia et gynecologica Scandinavica, 102(9), 1210–1218.
  • Halcion Prescribing Information. Available online at https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/017892s049lbl.pdf. [Accessed Jan 2025]
  • Kallen B, et al. 2013. The use of central nervous system active drugs during pregnancy. Pharmaceuticals 6(10):1221-1286.
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  • Matsuo A, et al. 1979. Reproduction studies of triazolam in rats and rabbits. Iyakuhin Kenkyu 10:52-67.
  • Noh Y, et al. 2022. First-trimester exposure to benzodiazepines and risk of congenital malformations in offspring: A population-based cohort study in South Korea. PLoS Med; 19(3):e1003945.
  • Sakai T, et al. 1996. Triazolam (Halcion) intoxication in a neonate–a first report [letter]. Eur J Pediatr; 155:1065-6.


Triazolam (Halcion®)

Selected References:

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  • Hale, TW. 2012. Medications and Mothers’ Milk. Fifteenth Edition. Amarillo, TX: Hale Publishing L.P.
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  • Jick H, et al. 1981. First-trimester drug use and congenital disorders. JAMA,246(4):343-346.
  • Laden S. 2019. OTC Medication Use in Pregnancy and Breastfeeding. US Pharmacist, 44(9):16-19
  • Lameris AL, et al. 1979. Drug induced alterations in Mg2+ homeostasis. Clinical Science,123(1):1.
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  • Mahadevan U, & Kane S. 2006. American Gastroenterological Association Institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology,131(1):283-311.
  • Rungsiprakarn P, et al. 2015. Interventions for treating constipation in pregnancy. Cochrane Database Syst Rev, Sep 4;2015(9):CD011448
  • Schindler AM. 1984. Isolated neonatal hypomagnesaemia associated with maternal overuse of stool softener. Lancet,2:822.
  • Thorpe PG, et al. 2013. Medications in the first trimester of pregnancy: most common exposures and critical gaps in understanding fetal risk. Pharmacoepidemiol Drug Safe, 22(9): 1013-1018.
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Triazolam (Halcion®)

Selected References:

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Triazolam (Halcion®)

Selected References:  

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  • Avni-Biron, I.,et al. 2022. Ustekinumab during pregnancy in patients with inflammatory bowel disease: a prospective multicentre cohort study. Alimentary pharmacology & therapeutics, 56(9), 1361–1369.  
  • Beaulieu D, et al. 2018. Use of Biologic Therapy by Pregnant Women with Inflammatory Bowel Disease does Not affect Infant Response to Vaccines. Clin Gast & Hep; 16:99-105. 
  • Chaparro Sanchez M, et al. 2022. Live vaccines in children exposed to biological agents for IBD in utero and/or during breastfeeding: Are they safe? Results from the Dumbo registry of GETECCU. United European Gastroenterol J 2022;10:757-8.  
  • Chugh, R., et al. 2024. Maternal and Neonatal Outcomes in Vedolizumab- and Ustekinumab-Exposed Pregnancies: Results From the PIANO Registry. The American journal of gastroenterology, 119(3), 468–476.  
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  • Meserve, J., 2021. Paternal Exposure to Immunosuppressive and/or Biologic Agents and Birth Outcomes in Patients With Immune-Mediated Inflammatory Diseases. Gastroenterology, 161(1), 107–115.e3.  
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Triazolam (Halcion®)

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