Ziprasidone (Geodon®)

Selected References:

  • Anghelescu I, et al. 2004. Successful switch to aripiprazole after induction of hyperprolactinemia by ziprasidone: a case report. J Clin Psychiatry; 65:1286-1287. 
  • Biesdorf C, et al. 2019. Physiologically-based pharmacokinetics of ziprasidone in pregnant women. Br J Clin Pharmacol; 85(5):914-923.  
  • Bode’n R, et al. 2012. Antipsychotics During Pregnancy Relation to Fetal and Maternal Metabolic Effects. Arch Gen Psychiatry; 69(7):715-721. 
  • Cho H, et al. 2025. Antipsychotic use during pregnancy and outcomes in pregnant individuals and newborns. J Affect Disord; 373:495-504. 
  • Creeley CE, et al. 2019. Use of Prescribed Psychotropics during Pregnancy: A Systematic Review of Pregnancy, Neonatal, and Childhood Outcomes. Brain Sci; 9(9),235.   
  • Damkier P, Videbech P. 2018. The safety of second-generation antipsychotics during pregnancy: A clinically focused review. CNS Drugs. 32(4):351-366. 
  • Einarson A, Boskovic R. 2009. Use and safety of antipsychotic drugs during pregnancy. J Psychiatr Pract; 15(3):183-192. 
  • FDA. 2011. Drug Safety Communication: Antipsychotic drug labels updated on use during pregnancy and risk of abnormal muscle movements and withdrawal symptoms in newborns (issued 2/2011). https://www.fda.gov/Drugs/DrugSafety/ucm243903.htm  
  • FDA 2014.  Drug Safety Communication: FDA reporting mental health drug ziprasidone (Geodon) associated with rare but potentially fatal skin reactions. (Issued 12/2014). https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-reporting-mental-health-drug-ziprasidone-geodon-associated-rare. 
  • Ginsberg DL. 2003. Ziprasidone-induced galactorrhea. Prim Psychiatry; 10:22-23. 
  • Ginsbery DL. 2004. Ziprasidone-induced hyperprolactinemia. Prim Psychiatry; 11:26–27.
  • Goodnick PJ, et al. 2002. Antipsychotics: Impact on prolactin levels. Expert Opin Pharmacother; 3:1381–1391. 
  • Haddad PM, Wieck A. 2004. Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management. Drugs; 64:2291-2314.  
  • Heinonen E, et al. 2022. Antipsychotic Use During Pregnancy and Risk for Gestational Diabetes: A National Register-Based Cohort Study in Sweden. CNS drugs; 36(5):529–539. 
  • Humby T, Davies W. 2019. Brain gene expression in a novel mouse model of postpartum mood disorder. Trans Neurosci; 10:168-174.  
  • Huybrechts KF, et al. 2016. Antipsychotic use in pregnancy and the risk for congenital malformations. JAMA Psychiatr; 73(9):938-46. 
  • Huybrechts KF, et al. 2023. Association of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US. JAMA psychiatry; 80(2):156–166. 
  • Jordan MP. 2003. Ziprasidone-associated galactorrhea in a female teenager. J Am Acad Child Adolesc Psychiatry; 42:4-5. 
  • Khan SJ, et al. 2016. Bipolar disorder in pregnancy and postpartum: Principles of management. Curr Psychiatry Rep; 18(2):13.  
  • Kopecek M, et al. 2005. Ziprasidone-induced galactorrhea: A case report. Neuro Endocrinol Lett; 26:69–70. 
  • Kulkarni J, et al. 2015. Antipsychotic use in pregnancy. Expert Opin Pharmacother; 16(9):1335-1345. 
  • Lusskin SI, et al. 2004. Prolactin Elevation with Ziprasidone. American Journal of Psychiatry; 161(10): 1925. 
  • Maguire GA. 2002. Prolactin elevation with antipsychotic Medications: Mechanisms of action and clinical consequences. J Clin Psychiatry; 63 Suppl 4:56–62. 
  • McCauley-Elsom K, et al. 2010. Antipsychotics in pregnancy. Psychiat Ment Health Nurs 17(2):97-104.  
  • Myers WT. 2014. A lactating adolescent on atypical antipsychotics: A case report of an emerging challenge. J Investig Med; 62:485. 
  • Park Y, et al. 2018. Continuation of atypical antipsychotic medication during early pregnancy and the risk of gestational diabetes. Am J Psychiatry; 175(6):564-574 
  • Peitl MV, et al. 2010. Ziprasidone as a possible cause of cleft palate in a newborn. Psychiatr Danub; 22(1):117-119. 
  • Ramadan M, et al. 2005. D2-blockade and possible ziprasidone-induced galactorrhea. Int Clin Psychopharmacol; 20:113–114. 
  • Raza S, Haq F. 2010. Ziprasidone-induced galactorrhea in an adolescent female: A case report. Prim Care Companion J Clin Psych; 12(3):PCC.09l00855 
  • Ruzic K, et al. 2009. Pregnancy and atypical antipsychotics. Psychiatr Danub; 21(3):368-370.  
  • Saldaña SN, Delgado SV. 2007. Ziprasidone-associated galactorrhea in an adolescent female. J Child Adolesc Psychopharmacol; 17:259–260. 
  • Schlotterbeck P, et al. 2009. Low concentration of ziprasidone in human milk: a case report. Int J Neuropsychopharmacology; 12(3) 437–438.  
  • Sørensen MJ, et al. 2015. Risk of fetal death after treatment with antipsychotic medications during pregnancy. PLoS One; 10(7): e0132280.  
  • Straub L, et al. 2026. Congenital malformation risk following prenatal antipsychotic exposure: a systematic safety surveillance approach. BMJ Ment Health; 29(1):e302270.  
  • Wang E, et al. 2025. Comparative Safety of Antipsychotic Medications and Mood Stabilizers During Pregnancy: A Systematic Review and Network Meta-analysis of Congenital Malformations and Prenatal Outcomes. CNS Drugs; 391–22. 
  • Werremeyer A. 2009. Ziprasidone and citalopram use in pregnancy and lactation in a woman with psychotic depression. Am J Psychiatry; 166(11):1298. 
  • Uguz F. 2016. Second-generation antipsychotics during the lactation period: A comparative systematic review on infant safety. J Clin Psychopharmacol; 36:244-252.  
  • Uguz FJ. 2019. Antipsychotic use during pregnancy and the risk of gestational diabetes mellitus: A systematic review. Clin Psychopharmacol; 39(2):162-167.


Ziprasidone (Geodon®)

Selected References:  

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  • Centers for Disease Control and Prevention (CDC). 2003. Guidelines for Infection Control in Dental Health-Care Settings. Morbidity and Mortality Weekly Report (MMWR). 52(RR17):1-61.  
  • CDC. 2021. Summary of Infection Prevention Practices in Dental Settings: Basic Expectations for Safe Care. Available athttps://www.cdc.gov/oralhealth/infectioncontrol/summary-infection-prevention-practices/index.html https://www.cdc.gov/dental-infection-control/hcp/summary/index.html 
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  • Warwick D, et al. 2019. Mercury vapor volatilization from particulate generated from dental amalgam removal with a high-speed dental drill – a significant source of exposure. Jrnl of Occ Med & Tox. 14,22. 
  • United States Food and Drug Administration (FDA). 2017. About Dental Amalgam Fillings.  https://www.fda.gov/medical-devices/dental-devices/dental-amalgam-fillings [Accessed May 2026]. 


Ziprasidone (Geodon®)

Selected References:

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  • McPherson TD, et al. 2020. Mumps Cases Disproportionately Affecting Persons Living with HIV Infection and Men Who Have Sex with Men – Chicago, Illinois, 2018. MMWR Morb Mortal Wkly Rep; 69(28):909-912. 
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  • Utz JP, et al. 1964. Clinical and Laboratory Studies of Mumps. N Engl J Med; 270:1283-6.  
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Ziprasidone (Geodon®)

Selected References:

  • Carvajal A, et al. 2015. Emergency contraceptive pill safety profile. Comparison of the results of a follow-up study to those coming from spontaneous reporting. Pharmacoepidemiology and Drug Safety; 24(1): 93–97. 
  • De Santis M, et al. 2005. Failure of the emergency contraceptive levonorgestrel and the risk of adverse effects in pregnancy and on fetal development: an observational cohort study. Fertility and Sterility; 84(2):296–299. 
  • Endler M, et al. 2022. Effect of levonorgestrel emergency contraception on implantation and fertility: A review. Contraception; 109:8-18.  
  • Gainer E, et al. 2007. Levonorgestrel pharmacokinetics in plasma and milk of lactating women who take 1.5 mg for emergency contraception. Hum Reprod; 22(6):1578-84. 
  • Leelakanok N. & Methaneethorn J. 2020. A systematic review and meta-analysis of the adverse effects of levonorgestrel emergency oral contraceptive. Clinical Drug Investigation; 40(5):395–420. 
  • Mierzejewska A, et al. 2024. Emergency contraception – a narrative review of literature. Eur J Obstet Gynecol Reprod Biol; 299:188-192. 
  • Polakow-Farkash S et al. 2013. Levonorgestrel used for emergency contraception during lactation-A prospective observational cohort study on maternal and infant safety. J Matern Fetal Neonatal Med; 26:219-221.  
  • Shohel M, et al. 2014. A systematic review of effectiveness and safety of different regimens of levonorgestrel oral tablets for emergency contraception. BMC Women’s Health; 14(54).  
  • Shurie S, et al. 2018. Levonorgestrel only emergency contraceptive use and risk of ectopic pregnancy in Eldoret Kenya: a case-control study. The Pan African Medical Journal; 31(214).  
  • Shaaban OM et al. 2019. Levonorgestrel emergency contraceptive pills use during breastfeeding; effect on infants’ health and development. J Matern Fetal Neonatal Med; 32:2524–2528.  
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  • von Hertzen H, et al. 2002. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomised trial. Lancet; 360(9348):1803-1810. 
  • Zhang J, et al. 2015. Association between levonorgestrel emergency contraception and the risk of ectopic pregnancy: a multicenter case-control study. Sci Rep; 5(8487).  


Ziprasidone (Geodon®)

Selected References:  

  • American College of Obstetricians and Gynecologists (ACOG). 2018. ACOG Committee Opinion No. 733: Employment Considerations During Pregnancy and the Postpartum Period. Obstet Gynecol; 131(4):e115-e123, reaffirmed 2023.  
  • Centers for Disease Control and Prevention (CDC). 2025. Breastfeeding and special circumstances- occupational exposures. Available at URL: https://www.cdc.gov/breastfeeding-special-circumstances/hcp/exposures/occupational.html [Last accessed May 2026]. 
  • Charkiewicz AE, et al. 2020. Lead Toxicity and Pollution in Poland. Int J Environ Res Public Health. 17(12):4385.  
  • Dietz M, et al. 2023. The relevance of oral exposure in the workplace: a systematic review and meta-analysis. Front Public Health.11:1298744.  
  • Goede H, et al. 2024. Meta-analysis of the quantitative effectiveness of risk management measures (RMM) in the workplace. Annals of Work Exposures and Health; 68(5), 495–509. 
  • Grajewski B, et al. 2005. Occupational exposures and reproductive health: 2003 Teratology Society Meeting Symposium summary. Birth Defects Res B Dev Reprod Toxicol; 74(2):157-63. 
  • Günal A, Demirtürk F. 2022. Occupational hazards, sleep quality and musculoskeletal problems of pregnant workers. J Obstet Gynaecol; 42(2):215-219. 
  • Holland MG, et al. 2016. Workplace Lead Exposure. J Occup Environ Med. 58(12):e371-e374.  
  • Occupational Safety and Health (OSHA) Reproductive Hazards Overview: https://www.osha.gov/reproductive-hazards [Last accessed May 2026]. 
  • Ohlander J, et al. 2020. Interventions to Reduce Exposures in the Workplace: A Systematic Review of Intervention Studies Over Six Decades, 1960-2019. Front Public Health. 8:67.  
  • Paul M. 1997. Occupational reproductive hazards. Lancet; 349(9062):1385-8.  
  • Rice HR, Baker BA. 2007. Workplace hazards to women’s reproductive health. Minn Med; 90(9):44-7.  
  • U.S. Centers for Disease Control National Institute for Occupational Safety and Health (NIOSH). 2024. Reproductive Health and The Workplace. About Reproductive Health in the Workplace. https://www.cdc.gov/niosh/reproductive-health/about/. [Last accessed May 2026].  
  • US Department of Health and Human Services, Cincinnati (OH), 1995NIOSH. The National Institute for Occupational Safety and Health (2024). Hierarchy of Controls https://www.cdc.gov/niosh/hierarchy-of-controls/about/. [Last accessed May 2026].