Better Safety Info in Pregnancy Starts with Your Referral

Rigorously Designed Research

MotherToBaby Pregnancy Studies partners with physicians and patients to monitor pregnancy exposure to select medications. Our strong cohort study design allows our team to tease apart risks that may be associated with underlying disease versus those associated with a medication exposure, resulting in evidence-based findings that you and pregnant your patients can use when making treatment decisions.

Referral Is Easy & Patients Self-Enroll

1- Refer: All you need to do is refer your patients to us. Women self-enroll, so after you make the referral nothing further is required from you.

2 – Observation: Our research is by observation only — we will not ask your patient to take or change any medications or change any part of her healthcare routine

3 – Participation: Women complete 1-3 phone interviews during pregnancy and at least 1 after pregnancy, and authorize the release of medical records for the pregnancy and for their baby.

Please consider referring your patients if they fall into either of these two groups:

  1. Patients who have taken any of the following medications during a current pregnancy:
  • Apremilast (Otezla®)
  • Benralizumab (Fasenra®)
  • Certolizumab-pegol (Cimzia®)
  • COVID-19 Vaccines
  • Dupilumab (Dupixent®)
  • Guselkumab (Tremfya®)
  • Leflunomide (Arava®)
  • Mepolizumab (Nucala®)
  • Prucalopride (Motegrity®)
  • Teriflunomide Aubagio®
  • Tildrakizumab (Ilumya™) 
  • Tocilizumab (Actemra®)
  • Tofacitinib (Xeljanz®)
  • Sarilumab (Kevzara®)

2. Patients who have the following conditions and have not taken the above medications during pregnancy.

  • Ankylosing Spondylitis
  • Asthma
  • Atopic Dermatitis
  • Crohn’s Disease
  • COVID-19
  • Functional Constipation
  • Juvenile Idiopathic Arthritis
  • Multiple Sclerosis
  • Psoriasis
  • Psoriatic Arthritis
  • Rheumatoid Arthritis
  • Ulcerative Colitis

Patient Education & Provider Resources

MotherToBaby is a service of the non-profit Organization of Teratology Information Specialists (OTIS). In addition to conducting pregnancy registry studies, we are dedicated to providing no-cost evidence-based information to mothers and health professionals about medications and other exposures during pregnancy and lactation. We can provide you with patient and provider resources including:

  • Patient-friendly Fact Sheets
  • Patient Brochures
  • Teratogen Information Services

Refer Your Patient to Our Observational Studies

Find out more about our observational pregnancy research studies by contacting our team. Our staff is dedicated to supporting healthcare professionals. Please select if you would like to learn more about patient referrals or to learn more about our resources.

Advancing Medication Safety Information in Pregnancy

The Society for Maternal-Fetal Medicine is partnering with MotherToBaby Pregnancy Studies to encourage our member physicians to refer your pregnant patients to pregnancy exposure registries. With your help, these registries will yield much-needed safety information on medication use in pregnancy.

Questions? Call 866.626.6847 | Text 855.999.3525 | Email or Chat at

Disclaimer: MotherToBaby Fact Sheets are meant for general information purposes and should not replace the advice of your health care provider. MotherToBaby is a service of the non-profit Organization of Teratology Information Specialists (OTIS). OTIS/MotherToBaby encourages inclusive and person-centered language. While our name still contains a reference to mothers, we are updating our resources with more inclusive terms. Use of the term mother or maternal refers to a person who is pregnant. Use of the term father or paternal refers to a person who contributes sperm. Copyright by OTIS, September 1, 2021.