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MotherToBaby

Medications and More during pregnancy and breastfeeding

Clozapine

Selected References:

  • Beex-Oosterhuis MM, et al. 2021. Clozapine Treatment During Pregnancy and the Postpartum Period: A Systematic Literature Review. J Clin Psychiatry. 83(1):21r13952.
  • Bolu A, Akgün A, Öznur T, Çelik C. 2018. Low-dose clozapine-induced retrograde ejaculation. Psychiatry Clin Neurosci; 72(7):541-542.
  • Borisch C, et al. 2012. Severe neutropenia in a newborn after clozapine therapy during pregnancy. Reprod Toxicol; 34:158.
  • Clozapine Package Insert: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019758s073lbl.pdf
  • Damkier P and Videbach P. 2018. The Safety of Second-Generation Antipsychotics During Pregnancy: A Clinically Focused Review. CNS Drugs; 32:351–366.
  • Dev VJ, Krupp P. 1995. Adverse event profile and safety of clozapine. Rev Contemp Pharmacother.;6:197–208.
  • Haddad PM, Wieck A, Haddad PM, Wieck A. 2004. Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management. Drugs; 64(20):2291-314.
  • Imaz ML, Oriolo G, Torra M, et al. 2018. Clozapine use during pregnancy and lactation: A case-series report. Front Pharmacol.;9:264.
  • Larsen ER, Damkier P, Pedersen LH, et al. 2015. Use of psychotropic drugs during pregnancy and breast-feeding. Acta Psychiatr Scand Suppl.;132 Suppl 445:1–28.
  • Mehta TM, Van Lieshout RJ. 2017. A review of the safety of clozapine during pregnancy and lactation. Arch Womens Ment Health;20(1):1-9.
  • Shao P, Ou J, Peng M, Zhao J, Chen J, Wu R. 2015. Effects of clozapine and other atypical antipsychotics on infants development who were exposed to as fetus: a post-hoc analysis. PLoS One 10(4):e0123373.
  • Thanigaivel R, et al. 2022 A systematic review of maternal and infant outcomes after clozapine continuation in pregnancy. Int J Psychiatry Clin Pract.26(2):178-182.
  • Uguz F. 2021. A new safety scoring system for the use of psychotropic drugs during lactation. Am J Ther.28:e118–e126.
  • Uguz F. 2016. Second-generation antipsychotics during the lactation period: A comparative systematic review on infant safety. J Clin Psychopharmacol.;36:244–52.
  • Uygur OF, Uygur H. 2019. Neurodevelopmental and growth follow-up of the baby exposed to antipsychotics during pregnancy and lactation: A case report. Psychiat Clin Psychopharmacol.;29:744–7.
  • Uguz F. 2020. The use of clozapine during pregnancy and lactation: A case report. Psychiat Clin Psychopharmacol.;30:193–5.

MotherToBaby cuenta con el apoyo de la Administración de Recursos y Servicios de Salud (HRSA) del Departamento de Salud y Servicios Humanos de los Estados Unidos (HHS) como parte de una adjudicación por un total de $6,000,000 con cero porcentaje financiado con fuentes no gubernamentales. Los contenidos son los del autor/es y no representan necesariamente los puntos de vista oficiales de, ni un respaldo, por HRSA, HHS o el Gobierno de los Estados Unidos.