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MotherToBaby

Medications and More during pregnancy and breastfeeding

Clozapine

Selected References:

  • Beex-Oosterhuis MM, et al. 2021. Clozapine treatment during pregnancy and the postpartum period: a systematic literature review. J Clin Psychiatry; 83(1):21r13952. 
  • Bolu A, et al.  2018. Low-dose clozapine-induced retrograde ejaculation. Psychiatry Clin Neurosci; 72(7):541-542. 
  • Borisch C, et al. 2012. Severe neutropenia in a newborn after clozapine therapy during pregnancy. Reprod Toxicol; 34:158. 
  • Damkier P & Videbach P. 2018. The safety of second-generation antipsychotics during pregnancy: a clinically focused review. CNS Drugs; 32:351–366. 
  • Dev VJ & Krupp P. 1995. Adverse event profile and safety of clozapine. Rev Contemp Pharmacother; 6:197–208. 
  • Grover S, Gupta S. 2025. Use of clozapine in pregnancy: a retrospective study from North India. Journal of Clinical Psychopharmacology; 45(4):353-355.  
  • Haddad PM, et al. 2004. Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management. Drugs; 64(20):2291-2314. 
  • Husain K, et al. 2025. Limitations in Recent Study of Clozapine Use During Pregnancy. J Clin Psychopharmacol; 45(6):688-689. 
  • Imaz ML,et al. 2018. Clozapine use during pregnancy and lactation: A case-series report. Front Pharmacol; 9:264. 
  • Jing H, Tang X. 2026. Risk factors for drug-related gestational diabetes mellitus: a real-world pharmacovigilance study based on the FAERS database. BMC Pregnancy Childbirth; 26(1):687.  
  • Kulkarni J, et al. 2026. Clozapine safety in pregnancy: a clinical study. Schizophrenia Bulletin; 52(2):sbae132.  
  • Larsen ER, et al. 2015. Use of psychotropic drugs during pregnancy and breast-feeding. Acta Psychiatr Scand Suppl; 132 Suppl 445:1–28.  
  • Mehta TM, et al. 2017. A review of the safety of clozapine during pregnancy and lactation. Arch Womens Ment Health; 20(1):1-9. 
  • Shao P, et al. 2015. Effects of clozapine and other atypical antipsychotics on infants development who were exposed to as fetus: a post-hoc analysis. PLoS One; 10(4):e0123373. 
  • Thanigaivel R, et al.  2022 A systematic review of maternal and infant outcomes after clozapine continuation in pregnancy. Int J Psychiatry Clin Pract; 26(2):178-182. 
  • Tsukiji M, et al. 2025. A Japanese pregnant woman with treatment-resistant schizophrenia who continued clozapine with blood concentration monitoring during the perinatal period and had a healthy baby: a case report. Neuropsychopharmacology Reports; 45(4):e70074.  
  • Uguz F. 2016. Second-generation antipsychotics during the lactation period: a comparative systematic review on infant safety. J Clin Psychopharmacol; 36:244–252.  
  • Uguz F. 2020. The use of clozapine during pregnancy and lactation: a case report. Psychiat Clin Psychopharmacol; 30:193–195. 
  • Uguz F. 2021. A new safety scoring system for the use of psychotropic drugs during lactation. Am J Ther; 28:e118–e126.  
  • Uygur OF, Uygur H. 2019. Neurodevelopmental and growth follow-up of the baby exposed to antipsychotics during pregnancy and lactation: A case report. Psychiat Clin Psychopharmacol; 29:744–747. 

MotherToBaby cuenta con el apoyo de la Administración de Recursos y Servicios de Salud (HRSA) del Departamento de Salud y Servicios Humanos de los Estados Unidos (HHS) como parte de una adjudicación por un total de $6,000,000 con cero porcentaje financiado con fuentes no gubernamentales. Los contenidos son los del autor/es y no representan necesariamente los puntos de vista oficiales de, ni un respaldo, por HRSA, HHS o el Gobierno de los Estados Unidos.