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MotherToBaby

Medications and More during pregnancy and breastfeeding

Dupilumab (Dupixent®)

Selected References:

  • Akhtar NH et. al. 2022. The use of dupilumab in severe atopic dermatitis during pregnancy: a case report. Allergy Asthma Clin Immunol. 18(1):9.  
  • Avallone G, et al. 2024. Association between maternal dupilumab exposure and pregnancy outcomes in patients with moderate-to-severe atopic dermatitis: A nationwide retrospective cohort study. J Eur Acad Dermatol Venereol. 6(1)1-10. 
  • Bosma AL, et al. 2021. Paternal and maternal use of dupilumab in patients with atopic dermatitis: a case series. Clin Exp Dermatol. 46(6):1089-1092. 
  • Center for Drug Evaluation and Research (CDER). Dupilumab pharmacology review. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/761055Orig1s000PharmR.pdf.  Accessed 23 June 2026. 
  • Chan T, et al, 2020. Taiwanese Dermatological Association consensus for the management of atopic dermatitis: A 2020 update. J Formos Med Assoc. 120(1:Pt2):429-442. 
  • Chopra CR, et al. 2025. Maternal, Fetal, and Labour Outcomes of Dupilumab Use for Atopic Dermatitis During Pregnancy: A Systematic Review. J Cutan Med Surg. 29(1):51-55.  
  • Costley M, Murphy B. 2022. Severe atopic dermatitis treated successfully with dupilumab throughout pregnancy. 2022. Clin Exp Dermatol 47(5):960-961. 
  • Di Lernia V, Peccerillo F, 2024. Long-Term Follow-Up of Dupilumab Treatment During Conception, Pregnancy and Lactation. Indian J Dermatol. 69(2):193-195.  
  • Escolà H, et al. 2023. Dupilumab for atopic dermatitis during pregnancy and breastfeeding: Clinical experience in 13 patients. J Eur Acad Dermatol Venereol. 37(9)p.e1156-e1160. 
  • Gracia-Darder I, et al. 2022). Patient with atopic dermatitis, hyper IgE syndrome and ulcerative colitis, treated successfully with dupilumab during pregnancy. Dermatol Ther. 35(2) e15247. 
  • Hong N, et al. 2024. Atopic dermatitis treated safely with dupilumab during pregnancy and lactation: A case series of four patients. Australas J Dermatol. 00:1-4. 
  • Heilskov S, et al. 2020. Immunosuppressive and Immunomodulating Therapy for Atopic Dermatitis in Pregnancy: An Appraisal of the Literature. Dermatol Ther (Heidelb) 10(6): 1215–1228. 
  • Jang W, et al. 2025. Use of Biologics to Treat Asthma during Pregnancy and Adverse Events in Pregnant Women and Newborns: A Global Pharmacovigilance Analysis. Int Arch Allergy Immunol. 186(9):875-888.  
  • Kage P, et al. 2020. A case of atopic eczema treated safely with dupilumab during pregnancy and lactation. Journal of the European Academy of Dermatology and Venereology: JEADV, 34(6), e256–e257. 
  • Kage P, et al. 2021. Case of atopic eczema treated with dupilumab throughout conception, pregnancy, and lactation. J Dermatol 48(10):E484-E485. 
  • Khamisy-Farah R, et al. 2021. Safety profile of Dupilumab during pregnancy: a data mining and disproportionality analysis of over 37,000 reports from the WHO individual case safety reporting database (VigiBase™) Eur Rev Med Pharmacol Sci. 25(17):5448-5451. 
  • Lobo Y, et al. 2021. Atopic Dermatitis Treated Safety with Dupilumab during Pregnancy: A Case Report and Review of the Literature. Case Rep Dermatol. 13:248–256. 
  • Metko, D. et al. 2024. A real-world study of dupilumab in patients with atopic dermatitis including patients with malignancy and other medical comorbidities. JAAD Int. 15:5-11. 
  • Mian M, et al. 2020. Dupilumab for the treatment of severe atopic dermatitis in a pregnant patient: A case report. JAAD Case Reports. 6(10), 1051–1052.   
  • Napolitano M, et al. 2021. New emergent therapies for atopic dermatitis: A review of safety profile with respect to female fertility, pregnancy, and breastfeeding. Dermatol Ther. 34:e14475.   
  • Preuß S, et al. 2025. Dupilumab shows no elevated risk for maternal adverse pregnancy outcomes: A propensity-matched cohort study. J Eur Acad Dermatol Venereol. 39(9):1576-1587.  
  • Riquelme-Mc Loughlin C, Mascaró JM Jr. 2021. Treatment of pemphigoid gestationis with dupilumab. Clin Exp Dermatol. 46(8):1578-1579.  
  • Sánchez-García V, et al 2025. Safety of dupilumab therapy for atopic dermatitis during pregnancy: A systematic review and meta-analysis. Acta Derm Venereol.105:adv41307.  
  • Sanofi-Aventis U.S. Dupixent® Prescribing Information. Available online at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?.  Accessed on 23 June 2026.  
  • Vestergaard C, et al. 2019. European task force on atopic dermatitis position paper: treatment of parental atopic dermatitis during preconception, pregnancy and lactation period. J Eur Acad Dermatol Venereol. 33(9):1644-1659. 

MotherToBaby cuenta con el apoyo de la Administración de Recursos y Servicios de Salud (HRSA) del Departamento de Salud y Servicios Humanos de los Estados Unidos (HHS) como parte de una adjudicación por un total de $6,000,000 con cero porcentaje financiado con fuentes no gubernamentales. Los contenidos son los del autor/es y no representan necesariamente los puntos de vista oficiales de, ni un respaldo, por HRSA, HHS o el Gobierno de los Estados Unidos.