MotherToBaby

Medications and More during pregnancy and breastfeeding

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Medroxyprogesterone acetate (Depo Provera®)

Selected References:

  • Baheiraei A, et al. 2001. Effects of progestogen-only contraceptives on breast-feeding and infant growth Int J Gynaecol Obstet, 74; 203–205
  • Borgatta L, et al. 2002. Pregnancies diagnosed during Depo- Provera use. Contraception. Sep;66(3):169-72.
  • Callahan R et al. 2015. Ectopic pregnancy with use of progestin-only injectables and contraceptive implants: A systemic review. Contraception 92(6):514-22.
  • Dahlberg K. 1982. Some effects of depotmedroxyprogesterone acetate (DMPA): Observations in the nursing infant and in the long-term user. Int J Gynaecol Obstet 20:43-48.
  • Gray RH and Pardthaisong T. 1991. In utero exposure to steroid contraceptives and outcome of pregnancy. Am J Epidemiol 134:795-803.
  • Hogue CJ. 1991. Invited commentary: the contraceptive technology tightrope. Am J Epidemiol 134: 812-815; author response 816-817.
  • Jaffe B et al. 1990. Health, growth and sexual development of teenagers exposed in utero to medroxyprogesterone acetate. Paediatr Perinat Epidemiol 4:184-95.
  • Jimenez J et al. 1984. Long-term follow-up of children breast-fed by mothers receiving depotmedroxyprogesterone acetate. Contraception 30:523-533.
  • Koetsawang S, et al. 1982. Transfer of contraceptive steroids in milk of women using long-acting gestagens. Contraception 25:321- 331.
  • Pardthaisong T, et al. 1992. The long-term growth and development of children exposed to Depo-Provera during pregnancy or lactation. Contraception 45:313-24.
  • Pardthaisong T, Gray R. 1988. Steroid contraceptive use and pregnancy outcome. Teratology 38:51-58
  • PDR Entry for: Depo-Provera Contraceptive Injection. 2016. Pharmacia and Upjohn Company LLC.
  • Phillips SJ, et al. 2016. Progestogen-only contraceptive use among breastfeeding women: A systematic review. Contraception; 94:226-52.
  • Ratchanon S and Taneepanichskul S. 2000. Depot medroxyprogesterone acetate and basal serum prolactin levels in lactating women. Obstetrics & Gynecology 96(6):926-8.
  • Saxena BN et al. 1977. Levels of contraceptive steroids in breast milk and plasma of lactating women. Contraception 16:605-613.
  • Virutamasen P et al. 1996. Pharmacodynamic effects of depot-lprogesterone acetate (DMPA) administered to lactating women on their male infants. Contraception 54:153-157.
  • World Health Organization Department of Reproductive Health and Research. 2015. Medical eligibilty criteria for contraceptive use: Executive summary. Fifth ed. Geneva. https://apps.who.int/iris/bitstream/handle/10665/172915/WHO_RHR_15.07_eng.pdf;jsessionid=762D006358AF9A6F08B850657305578C?sequence=1 .
  • Yovich JL, et al. 1988. Medroxyprogesterone acetate therapy in early pregnancy has no apparent fetal effects. Teratology 38:135-144.