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Statins

Selected References:

  • Bateman BT, et al. 2015. Statins and congenital malformations: cohort study. BMJ,350:h1035.
  • Cleary KL, et al. 2014. Challenges of studying drugs in pregnancy for off-label indications: pravastatin for preeclampsia prevention. Semin Perinatol, 38(8):523-527.
  • Constantine MM, Cleary K. 2013. Pravastatin for the prevention of preeclampsia in high-risk pregnant women. Obstet Gynecol, 121(2 Pt 1):349-353.
  • Döbert M, et al. 2021. Pravastatin versus placebo in pregnancies at high risk of term preeclampsia. Circulation, 144(9):670-679.
  • Kazmin A, et al. 2007. Risk of statin use during pregnancy: a systematic review. J Obstet Gynaecol Can, 29(11):906.
  • Kusters DM, et al. 2012. Statin use during pregnancy: a systematic review and meta-analysis. Expert Rev Cardiovasc Ther, 10(3):363-378.
  • Maierean SM, et al. 2018. The potential role of statins in preeclampsia and dyslipidemia during gestation: a narrative review. Expert Opin Investig Drugs, 27(5):427-435.
  • McElhatton P. 2005. Preliminary data on exposure to statins during pregnancy. Reprod Toxicol, 20:471-472.
  • Morton S, Thangaratinam S. 2013. Statins in pregnancy. Curr Opin Obstet Gynecol, 25(6):433-440.
  • Ofori B, et al. 2007. Risk of congenital anomalies in pregnant users of statin drugs. Br J Clin Pharmacol, 64(4):496-509.
  • Omolaoye TS, et al. 2022. Statins and Male Fertility: Is There a Cause for Concern? Toxics, 10(627):1-19.
  • Taguchi N, et al. 2008. Prenatal exposure to HMG CoA reductase inhibitors: effects on fetal and neonatal outcomes. Reprod Toxicol, 26(2):175-177.
  • S. Food and Drug Administration. 2021. Statins: drug safety communication – FDA requests removal of strongest warning against using cholesterol-lowering statins during pregnancy. Posted July 20, 2021. Available at URL: https://www.fda.gov/safety/medical-product-safety-information/statins-drug-safety-communication-fda-requests-removal-strongest-warning-against-using-cholesterol.
  • Vahedian-Azimi A, et al. 2021. Effects of statins on preeclampsia: a systematic review. Pregnancy Hypertens, 23:123-130.
  • Vahedian-Azimi A, et al. 2021. Fetal toxicity associated with statins: a systematic review and meta-analysis. Atherosclerosis, 327:59-67.
  • Winterfeld U, et al. 2013. Pregnancy outcome following maternal exposure to statins: a multicentre prospective study. BJOG, 120(4):463-471.
  • Wolfgang P, et al. 2004. Pregnancy outcome after medication with HMG-CoA reductase inhibitors in the first trimester. Reprod Toxicol, 19:254-255.

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