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MotherToBaby

Medications and More during pregnancy and breastfeeding

Vitamin B12

Selected References:  

  • Ceyhan ST, et al. 2010. Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect. Gynecol Endocrinol. 26(8):578-581.  
  • Dror DK, Allen LH. 2018. Vitamin B-12 in human milk: A systematic review. Adv Nutr 9:358s-66s. 
  • Duggan C, et al. 2014. Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status. J Nutr. 144(5):758-764.  
  • Groenen PMW, et al. 2004. Marginal maternal vitamin B12 status increases the risk of offspring with spina bifida. Am J Obstet Gynecol 191(1):11-17. 
  • Hampel D, Allen LH. 2016. Analyzing B-vitamins in human milk: Methodological approaches. Crit Rev Food Sci Nutr 56:494-511. 
  • Lai JS, et al. 2019. Maternal plasma vitamin B12 concentrations during pregnancy and infant cognitive outcomes at 2 years of age. Br J Nutr. 121(11):1303-1312.
  • Munger RG, et al. 2021. Maternal vitamin B12 status and risk of cleft lip and cleft palate birth defects in Tamil Nadu State, India. Cleft Palate Craniofac J 58(5):567-576. 
  • National Institute of Health Office of Dietary Supplements. 2024. Vitamin B12: Fact Sheet for Health Professionals. Available at: https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/. Accessed 6 Jun 2024.  
  • Nelen WL, et al. 2000. Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis. Fertil Steril. 74(6):1196-1199. 
  • Ray JG, Blom HJ. 2003. Vitamin B12 insufficiency and the risk of fetal neural tube defects. QJM. 96(4):289-295. 
  • Ray JG, et al. 2007. Vitamin B12 and the risk of neural tube defects in a folic-acid-fortified population. Epidemiology 18(3):362-366. 
  • Reznikoff-Etievant MF, et al. 2002. Low Vitamin B(12) level as a risk factor for very early recurrent abortion. Eur J Obstet Gynecol Reprod Biol. 104(2):156-159. 
  • Senousy SM, et al. 2018. Association between biomarkers of vitamin B12 status and the risk of neural tube defects. J Obstet Gynaecol Res. 44(10):1902-1908.  
  • Suarez L, et al. 2003. Maternal serum B12 levels and risk for neural tube defects in a Texas-Mexico border population. Ann Epidemiol 13(2):81-88.  
  • Van Rooij IALM, et al. 2003. Vitamin and homocysteine status of mothers and infants and the risk of nonsyndromic orofacial clefts. Am J Obstet Gynecol 189(4):1155-1160.  
  • Wilson A, et al. 1999. A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab. 67(4):317-323. 
  • Zhang T, et al. 2009. Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China. Public Health Nutr. 12(5):680-686.  

 

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