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MotherToBaby

Medications and More during pregnancy and breastfeeding

​​Carvedilol (Coreg®)​

Selected References:  

  • American College of Obstetricians and Gynecologists (ACOG). 2019. ACOG Practice Bulletin No. 203 Summary: Chronic Hypertension in Pregnancy. Obstet Gynecol; 133(1): 215-219.  
  • Davis RL, et al. 2011. Risks of congenital malformations and perinatal events among infants exposed to calcium channel and beta-blockers during pregnancy. Pharmacoepidemiol Drug Saf; 20:138-145. 
  • Kubota K, et al. 2023. Alpha/beta- and beta-blocker exposure in pregnancy and the risk of neonatal hypoglycemia and small for gestational age. Circ J; 87: 569-577. 
  • Lennestal R, et al. 2009. Maternal use of antihypertensive drugs in early pregnancy and delivery outcome, notably the presence of congenital heart defects in the infants. Eur J Clin Pharmacol; 65(6): 615-625. 
  • McCowan LM, et al. 1996. Perinatal morbidity in chronic hypertension. Br J Obstet Gynecol; 103:123–129. 
  • Ray JG, et al. 2001. McMaster outcome study of hypertension in pregnancy. Early Hum Dev; 64:129–143. 
  • Rey E, Couturier A. 1994. The prognosis of pregnancy in women with chronic hypertension. Am J Obst Gynecol; 181:410–416. 
  • Sibal BM, et al. 2000. Preterm delivery in women with pregestational diabetes or chronic hypertension relative to women with uncomplicated pregnancies. The National Institute of Child Health and Human Development – Fetal Medicine Units Network. Am J Obst Gynecol; 183:1520–1524. 
  • Tanaka K, et al. 2016. Beta-blockers and fetal growth restriction in pregnant women with cardiovascular disease. Circ J; 80: 2221-2226. 
  • Waylis Therapeutics LLC. 2025. Coreg Product Label. Available at: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm. Accessed 12 June 2026.  
  • Yakoob MY, et al. 2013. The risk of congenital malformations associated with exposures to beta-blockers early in pregnancy: A meta-analysis. Hypertension; 62(2): 375-381. 

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