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​​Fluticasone (Flovent®, Flonase®)​

June 1, 2026

Selected References:  

  • American College of Obstetricians and Gynecologists Committee on Genetics. 2020. Management of women with phenylalanine hydroxylase deficiency (phenylketonuria). Obstet Gynec 135(4): e167-e-170.  
  • Alabdulrazzaq F, Koren G. 2012. Topical corticosteroid use during pregnancy. Can Fam Physician 58(6): 643–644. 
  • Alhussien AH, et al. 2018. Safety of intranasal corticosteroid sprays during pregnancy: an updated review. Eur Arch Otorhinolaryngol 275(2): 325–333. 
  • Battista MC, et al. 2016. Maternal inhaled fluticasone propionate intake during pregnancy is detected in neonatal cord blood. Bioanalysis, 8(14): 1441–1450. 
  • Bjørn AMB, et al. 2015. Use of inhaled and oral corticosteroids in pregnancy and the risk of malformations or miscarriage. Basic Clin Pharmacol Toxicol 116(4): 308–314. 
  • Blais L, et al. 2009. High doses of inhaled corticosteroids during the first trimester of pregnancy and congenital malformations. J Allergy Clin Immunol, 124(6): 1229-1234.e4. 
  • Charlton RA, et al. 2015. Safety of fluticasone propionate prescribed for asthma during pregnancy: A UK population-based cohort study. J Allergy Clin Immunol Pract 3(5): 772-9.e3. 
  • Clifton VL, et al. 2006. Effect of inhaled glucocorticoid treatment on placental 11β‐hydroxysteroid dehydrogenase type 2 activity and neonatal birthweight in pregnancies complicated by asthma. Aust N Z J Obstet Gynaecol 46(2): 136–140. 
  • Cossette B, et al. 2014. Relative perinatal safety of salmeterol vs formoterol and fluticasone vs budesonide use during pregnancy. Ann Allergy Asthma Immunol 112(5): 459–464. 
  • Dombrowski MP, et al. 2008. ACOG practice bulletin: clinical management guidelines for obstetrician-gynecologists number 90, February 2008: asthma in pregnancy. Obstet Gynecol, 111(2 Pt 1): 457-464. 
  • Edwards M J, et.al. 2003. Case-control study of cleft lip or palate after maternal use of topical corticosteroids during pregnancy. Am J Med Genet 120A(4): 459–463. 
  • Ellegård EK, et al. 2001. Fluticasone propionate aqueous nasal spray in pregnancy rhinitis. Clin Otolaryngol Allied Sci 26(5): 394–400. 
  • Källén B, Otterblad Olausson P. 2007. Use of anti-asthmatic drugs during pregnancy. 3. Congenital malformations in the infants. Eur J of Clin Pharmacol, 63(4): 383–388. 
  • Middleton PG ,et al. 2020. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J 55(2): 1901208. 
  • Mygind N, et al. 2001. Mode of action of intranasal corticosteroids. J Allergy Clin Immunol 108(1 Suppl): S16-25. 
  • Park-Wyllie L, et.al. 2000. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratol, 62(6): 385–392. 
  • Pradat P, et al. 2003. First trimester exposure to corticosteroids and oral clefts. Birth Defects Res A Clin Mol Teratol 67(12): 968–970. 
  • Rahimi R, et al. 2006. Meta-analysis finds use of inhaled corticosteroids during pregnancy safe: a systematic meta-analysis review. Hum Exp Toxicol 25(8): 447–452. 
  • Robijn AL, et al. 2019. Inhaled corticosteroid use during pregnancy among women with asthma: A systematic review and meta-analysis. Clin Exp Allergy  49(11): 1403–1417. 
  • Rocklin R. 2011. Asthma, asthma medications and their effects on maternal/fetal outcomes during pregnancy. Reprod Toxicol 32(2): 150. 
  • Rodríguez-Pinilla E, Martínez-Frías ML. 1998. Corticosteroids during pregnancy and oral clefts: a case-control study. Teratol, 58(1): 2–5. 
  • Tegethoff M, et.al. 2012. Inhaled glucocorticoids during pregnancy and offspring pediatric diseases: a national cohort study. Am J Respir Crit Care Med 185(5): 557–563. 
  • Van Zutphen AR, et al. 2015. Maternal asthma medication use during pregnancy and risk of congenital heart defects: Asthma Medication Use and Congenital Heart Defects. Birth Defects Res A Clin Mol Teratol 103(11): 951–961. 
  • Zaidi S, et al. 2019. Fetal concentrations of budesonide and fluticasone propionate: A study in mice. 
    AAPS J 21(4): 53. 

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