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Medications and More during pregnancy and breastfeeding

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Prednisone | Prednisolone

Selected References:

  • Briggs GG, et al. 2005. Drugs in pregnancy and lactation, 7th ed. Philadelphia, PA: Lippincott Williams & Wilkins.
  • Carmichael SL, et al. 2007. Maternal corticosteroid use and orofacial clefts. Am J Obstet Gynecol 197(6):585.e1-585.e7.
  • Constantinescu S, et al. 2014. Breast-feeding after transplantation. Best Pract Res Clin Obstet Gynaecol 28(8):1163-73.
  • Fitzsimons R, et al. 1986. Outcome of pregnancy in women requiring corticosteroids for severe asthma. J Allergy Clin Immunol 78(2):349-53.
  • Gomaa MF, et al. 2014. Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cerlls and clinical outcome in patients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial. Arch Gynecol Obstet 290:757–762.
  • Hendry WF, et al. 1990. Comparison of prednisolone and placebo in subfertile men with antibodies to spermatozoa. Lancet 335:85-8.
  • Ito S, et al. 1993. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol 168:1393-9.
  • Man YA, et al. 2009. Association of higher rheumatoid arthritis disease activity during pregnancy with lower birth weight: results of a national prospective study. Arthritis Rheum 60(11):3196-3206.
  • Nørgård B, et al. 2007. Therapeutic drug use in women with Crohn’s disease and birth outcomes: a Danish nationwide cohort study. Am J Gastroenterol 102:1406-13.
  • Nyberg G, et al. 1998. Breast-feeding during treatment with cyclosporine. Transplantation 65:253-5.
  • Ost L, et al. 1985. Prednisolone excretion in human milk. J Pediatr 106:1008-11.
  • Palmsten K, et al. 2019. Oral corticosteroid use during pregnancy and risk of preterm birth. Rheumatology (Oxford) Jun 1;59(6):1262-1271.
  • Park-Wyllie L, et al. 2000. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology 62(6):385-92.
  • Petri M, et al. 1992. The Hopkins Lupus Pregnancy Center: 1987-1991 update. Am J Reprod Immunol 28(3-4):188-91.
  • Pradat P, et al. 2003. First trimester exposure to corticosteroids and oral clefts. Birth Defects Res A Clin Mol Teratol 67(12):968-70.
  • Rodríguez-Pinilla E & Martínez-Frías ML. 1998. Corticosteroids during pregnancy and oral clefts: a case-control study. Teratology 58(1):2-5.
  • Ryu RJ, et al. 2018. Prednisone pharmacokinetics during pregnancy and lactation. J Clin Pharmacol Sep;58(9):1223-1232.
  • Skuladottir H, et al. 2014. Corticosteroid use and risk of orofacial clefts. Birth Defects Res (Part A) 100: 499-506.
  • Silver RK, et al. 1993. Comparative trial of prednisone plus aspirin versus aspirin alone in the treatment of anticardiolipin antibody – positive obstetrics patients. Am J Obstet Gynecol 169(6):1411-7.
  • Tata LJ, et al. 2008. Effects of maternal asthma, exacerbations and asthma medication use on congenital malformations in offspring: a UK population-based study. Thorax 63(11):981-87.
  • Van Zutphen AR, et al, National Birth Defects Prevention Study. 2015. Maternal asthma medication use during pregnancy and risk of congenital heart defects. Birth Defects Res A Clin Mol Teratol 103(11):951-61.
  • Xu L, et al. 2009. The influence of immunosuppressants on the fertility of males who undergo renal transplantation and on the immune function of their offspring. Transpl Immunol Dec;22(1-2):28-31.