Call Text Chat Email Refer a Patient Join a Study

Search

MotherToBaby

Medications and More during pregnancy and breastfeeding

Trazodone

Selected References:

  • Beeder LA, et al. 2010. Effect of antidepressant medications on semen parameters and male fertility. International Journal of Urology 27.1: 39-46. 
  • Dao K, et al. 2023. Reproductive safety of trazodone after maternal exposure in early pregnancy: a comparative ENTIS cohort study. Journal of Clinical Psychopharmacology 43.1: 12. 
  • Einarson A, et al. 2003. A multicentre prospective controlled study to determine the safety of trazodone and nefazodone use during pregnancy. Can J Psychiatry 48(2):106-110.  
  • Einarson A, et al. 2009. Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study. Can J Psychiatry 54(4):242 246.  
  • Glasgow-Osment B, et al. 2025. The effects of trazodone exposure during pregnancy on fetal outcomes: a systematic review. Eur J Clin Pharmacol 81: 1401-1408. 
  • Khazaie H, et al. 2013. Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial. Psychiatry Res. 210(3):901-5.  
  • McElhatton PR, et al. 1996. The outcome of pregnancy in 689 women exposed to therapeutic doses of antidepressants. A collaborative study of the European Network of Teratology Information Services (ENTIS). Reprod Toxicol 10:285-94. 
  • Misri S and Sivertz K. 1991. Tricyclic drugs in pregnancy and lactation: a preliminary report. Int J Psychiatry Med 21:157-171. 
  • Rivett KF and Barcelona PS. 1974. Toxicology of trazodone. Mod Probl Pharmacopsychiatry 9:76-86.  
  • Rosa F. 1994. Medicaid antidepressant pregnancy exposure outcomes. Reprod Toxicol 8(5):444-445. 
  • Verbeeck RK, et al. 1986. Excretion of trazodone in breast milk. Br J Clin Pharmacol 22(3):367-370.  

This website is supported by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) as part of an award totaling $1,200,000 with zero percentage financed with non-governmental sources. The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement by, HRSA, HHS, or the U.S. Government.