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MotherToBaby

Medications and More during pregnancy and breastfeeding

Clindamycin

Selected References:

  • Klebanoff MA, et al., 2023. Antibiotic treatment of bacterial vaginosis to prevent preterm delivery: Systematic review and individual participant data meta-analysis. Paediatr Perinat Epidemiol, 37(3):239-251. 
  • Lamont RF, et al. 2003. The efficacy of vaginal clindamycin for the treatment of abnormal genital tract flora in pregnancy. Infect Dis Obstet Gynecol, 11(4):181-189. 
  • Mackeen AD, et al. 2015. Antibiotic regimens for postpartum endometritis. Cochrane Database Syst Rev, 20(2):CD001067.  
  • Mann CF. 1980. Clindamycin and breast-feeding. Pediatrics, 66:1030-1031. 
  • McCormack WM, et al. 1987. Effect on birth weight of erythromycin treatment of pregnant women. Obstet Gynecol, 69:202-207. 
  • McGready R, et al. 2001. Randomized comparison of quinine-clindamycin versus artesunate in treatment of falciparum malaria in pregnancy. Trans R Soc Trop Med Hyg, 95:651-656. 
  • Mitrano JA, et al. 2009. Excretion of antimicrobials used to treat methicillin-resistant Staphylococcus aureus infections during lactation: safety in breastfeeding infants. Pharmacotherapy, 29(9):1103-1109.  
  • Muanda F, et al. 2017. Use of antibiotics during pregnancy and the risk of major congenital malformations: a population based cohort study. Br J Clin Pharmacol, 83:2557-2571. 
  • Nahum GG, et al. 2006. Antibiotic use in pregnancy and lactation: what is and is not known about teratogenic and toxic risks. Obstet Gynecol, 107(5):1120-1138.  
  • Ou MC, et al. 2001. Antibiotic treatment for threatened abortion during the early first trimester in women with previous spontaneous abortion. Acta Obstet Gynecol Scand, 80(8):753-756.  
  • Reboucas KF, et al. 2019. Treatment of bacterial vaginosis before 28 weeks of pregnancy to reduce the incidence of preterm labor. Int J Gynecol Obstet, 146(3):271-276. 
  • Smith JA, et al. 1975. Clindamycin in human breast milk. Can Med Assoc J, 112:806 
  • Steen B, Rane A. 1982. Clindamycin passage into human milk. Br J Clin Pharmacol, 13:661-664.  
  • Subtil D, et al. 2018. Early clindamycin for bacterial vaginosis in pregnancy (PREMEVA): a multicentre, double-blind, randomised controlled trial. Lancet, 392(10160):2171-2179.  
  • Ugwumadu A, et al. 2003. Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomised controlled trial. Lancet, 361:983-988. 
  • Weinstein AJ et al. 1976. Placental transfer of clindamycin and gentamicin in term pregnancy. Am J Obstet Gynecol, 124:688-691.  

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