MotherToBaby

Medications and More during pregnancy and breastfeeding

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Amitriptyline

Selected References:

  • American College of Obstetricians and Gynecologists (ACOG). 2018. Committee Opinion No. 753: Assessment and Treatment of Pregnant Women with Suspected or Confirmed Influenza. Obstet Gyn 132(4):e169-e173.
  • Berard A, et al. 2017. Antidepressant use during pregnancy and the risk of major congenital malformation in a cohort of depressed pregnant women: an updated analysis of the Quebec Pregnancy Cohort. BMJ Open 7:e013372.
  • Brixen-Rasmussen L, et al. 1982. Amitriptyline and nortriptyline excretion in human breast milk. Psychopharmacology 76:94-5.
  • Heinonen OP, et al. 1977. Birth Defect and Drugs in Pregnancy. Publishing Sciences Group Inc., Litteton, Mass.
  • Huybrechts KF, et.al. 2014. Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med. 370(25):2397-407.
  • Huybrechts KF, et al. 2015. Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn. Jama. 313(21):2142-51.
  • Lusskin SI, et al. 2018 Pharmacotherapy for Perinatal Depression. Clin Obstet Gynecol. doi:10.1097/grf.0000000000000365
  • Marhofer, D, et, al. 2021. Schmerztherapie in der Schwangerschaft [Pain management during pregnancy: An expert-based interdisciplinary consensus recommendation.] Schmerz. https://doi.org/10.1007/s00482-021-00571-4
  • McElhatton PR, et al. 1996. The outcome of pregnancy in 689 women exposed to therapeutic doses of antidepressants. A collaborative study of the European Network of Teratology Information Service (ENTIS). Reprod Toxicol 10:285-94.
  • Nulman I, et al. 1997. Neurodevelopment of children exposed in utero to antidepressant drugs, NEJM 336 (4):258-262.
  • Nulman I, et al. 2002. Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective controlled study. Am J Psychiatry 159(11):1889-1895.
  • Palmsten K, et al. 2013. Antidepressant use and risk for preeclampsia, Epidemiology 24(5): 682-691.
  • Tamai H, Kinugasa M. 2015. Pregnancy complicated by cyclic vomiting syndrome successfully treated with amitriptyline, Obstet Gynecol 125(6): 1487-1489.
  • Suthar N, et al. 2018 Galactorrhea with antidepressants: A case series. Indian Journal of Psychiatry. 60(1):145-6.
  • Tang KY. 2018. Amitriptyline poisoning at 34 weeks of pregnancy. Clin Toxicol (Phila). 56(4):301-3.
  • Uguz Faruk. 2017. Poor feeding and severe sedation in a newborn nursed by a mother on low dose amitriptyline. Breastfeed Med 12:67-8.
  • Vree PH, et al. 1985. A newborn infant with amitriptyline poisoning, Ned Tijdschr Geneeskd 129(19):910-912.
  • Yoshida K, et al. 1997. Investigation of pharmacokinetics and possible adverse effects in infants exposed to tricyclic antidepressants in breast-milk. J Affective Disord. 43:225-37.