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Buproprion (Wellbutrin®)

Selected References:

  • Alwan S, et al. 2010. Maternal use of bupropion and risk of congenital heart defects. Am J Obstet Gynecol 203(1):52.e1-6.
  • Anderson KN, et al 2020. Maternal use of specific antidepressants during early pregnancy and the risk of selected birth defects. JAMA Psychiatry; doi:10.1001/jamapsychiatry.2020.2453.
  • Baab S, et al. 2002. Serum bupropion levels in 2 breastfeeding mother-infant pairs. J Clin Psych 63:910-911.
  • Chaudron LH, et al 2004. Bupropion and breastfeeding: a case of possible infant seizure. J Clin Psych; 65:881-882.
  • Chun Fai-Chan B, et al. 2005. Pregnancy outcome of women exposed to bupropion during pregnancy: a prospective comparative study. Am J Obstet Gynecol 192(3):932-936.
  • Cole A, et al. 2007. Bupriopion in pregnancy and the prevalence of congenital malformations. Pharmacoepidemiol Drug Saf 10.1002/pds.1296.
  • Einarson T and Einarson A. 2005. Newer Antidepressants in pregnancy and rates of major malformations: a meta-analysis of prospective comparative studies. Pharmacoepi Drug Saf 14:823-827.
  • Einarson A, et al. 2009. Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study. Can J Psychiatry;54(4):242-246.
  • Figueroa R. 2010. Use of antidepressants during pregnancy and risk of attention-deficit/hyperactivity disorder in the offspring. J Dev Behav Pediatr 31(8):641.
  • Haas J, et al. 2004. Bupropion in breast milk: an exposure assessment for potential treatment to prevent post-partum tobacco use. Tob Control 13:52-56.
  • Halbreich U, et al. 1991. Menstrual irregularities associated with bupropion treatment. J Clin Psych 52:15-16.
  • Huybrechts KF, et al. 2014. Antidepressant use in pregnancy and risk of cardiac defects. NEJM; 370:2397-2407.
  • Källén B. 2004. Neonate characteristics after maternal use of antidepressants in late pregnancy. Arch Pediatr Adolesc Med 158(4):312-3016.
  • Kalra S, et al. 2005. Motherisk Update: Taking depressants during late pregnancy. Can Fam Physician 51:1077-1078.
  • Louik C, et al. 2014. First-trimester exposure to bupropion and risk of cardiac malformations. Pharmacoepidemiol Drug Saf; 23(10):1066-75.
  • Marks C, et al. 2021. Comparing newborn outcomes after prenatal exposure to individual antidepressants: A retrospective cohort study. Pharmacotherapy. 41(11):907-914.
  • Nanovskaya TN, et al. 2017. Bupropion sustained release for pregnant smokers: a randomized, placebo-controlled trial. Am J Obstet Gynecol. 216(4):420.e1-.e9.
  • Neuman G, et al. 2014. Bupropion and Escitalopram During Lactation. Ann Pharmaco.48(7):928-31.
  • Nonacs R, et al. 2005. Bupropion SR for the treatment of postpartum depression: a pilot study. Int J Neuropsychopharmacol 8(3):445-9.
  • Tharp MA, et al. 2022. Does lack of exposure to individual antidepressants at different points during pregnancy associate with reduced risk of adverse newborn outcomes? BMC Pregnancy Childbirth. 9;22(1):926.
  • The Bupropion Pregnancy Registry. Final report. 1 September 1997 through 31 March 2008. Issued August, 2008. Kendle International, Inc., Wilmington, North Carolina.

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