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MotherToBaby

Medications and More during pregnancy and breastfeeding

Clopidogrel (Plavix®)

Selected References: 

  • Al-Aqeedi RF, et al. 2008. Drug-eluting stent implantation for acute myocardial infarction during pregnancy with use of glycoprotein IIb/IIa inhibitor, aspirin, and clopidogrel. J Invasive Cardiol. 20(5):e146-e149. 
  • Arimura T, et al. 2009. Acute myocardial infarction associated with pregnancy successfully treated with percutaneous coronary intervention. Intern Med. 48(16):1383-1386. 
  • Babic Z, et al. 2011. Successful primary percutaneous coronary intervention in the first trimester of pregnancy. Catheter Cardiovasc Interv. 77(4):522-555. 
  • Balmain S, et al. 2007. Acute myocardial infarction during pregnancy successfully treated with primary percutaneous coronary intervention. Int J Cardiol. 116(3):e85-e87.  
  • Bauer MEB, et al. 2012. Peripartum management of dual antiplatelet therapy and neuraxial labor analgesia after bare metal stent insertion for acute myocardial infarction. Anesth Analg. 115(3):613-615. 
  • Boztosun B, et al. 2008. Treatment of acute myocardial infarction in pregnancy with coronary artery ballon angioplasty and stenting: use of tirofiban and clopidogrel. It J Cardiol. 127(3):413-416. 
  • De Santis M, et al. 2011. Clopidogrel treatment during pregnancy: a case report and a review of literature. Intern Med. 50(16):1769-1773. 
  • Geveart S, Schaubroeck H. 2021. Original data on pregnancy and ACS. Int J Cardiol Congenit Heart Dis. 5, (Supp 1). 
  • Klinzing P, et al. 2001. Case report: successful pregnancy and delivery after myocardial infarction and essential thrombocytopenia treated with clopidogrel. Clin Exp Obstet Gynecol. 28(4):215-216. 
  • Llinares Tello F, et al. 2007. [ST segment elevation acute coronary syndrome during pregnancy: a case report and review of therapeutic options] (Article in Spanish). Med Intensiva. 31(1):29-35. 
  • Martin M, et al. 2003. [Acute myocardial infarction during pregnancy. Treatment with clopidogrel] (Article in Spanish). Med Clin (Barc). 121(7):278-279. 
  • Myers GR, et al. 2011. Clopidogrel use throughout pregnancy in a patient with a drug-eluting coronary stent. Obstet Gynecol. (2 Pt 2):432-433. 
  • Nana M, et al. 2021. Antiplatelet therapy in pregnancy: A systematic review. Pharmacol Res. 168:105547.  
  • Nallamothu BK, et al. 2005. Clinical problem solving. Double jeopardy. N Engl J Med. 353(1):75-80.  
  • Narouze S, et al. 2018. Interventional spine and pain procedures in patients on antiplatelet and anticoagulant medications: guidelines from the American Society of Regional Anesthesia and Pain Medicine, the European Society of Regional Anaesthesia and Pain Therapy, the American Academy of Pain Medicine, the International Neuromodulation Society, the North American Neuromodulation Society, and the World Institute of Pain. Reg Anesth Pain Med. 43(3):225–262. 
  • O’Shanahan N, et al. 2006. [Acute coronary syndrome without ST elevation during pregnancy].(Article in Spanish). Med Intensiva. 30(4):180-182.  
  • Reilly CR, et al. 2014. Successful gestation and delivery using clopidogrel for secondary stroke prophylaxis: a case report and literature review. Arch Gynecol Obstet. 290(3):591-594. 
  • Santiago-Diaz P, et al. 2009. [Platelet antiaggregants in pregnancy] (Article in Spanish). Rev Esp Cardiol. 62(10):1197-1198. 
  • Sanofi-aventis US. 2022. Plavix prescribing information. Available at https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=de8b0b67-eb25-4684-83b5-7ad785314227&type=display#section-8.2. [Accessed April 2026]. 
  • Shah P, et al. 2004. Spontaneous dissection of the left main coronary artery. Can J Cardiol. 20(8):815-818.  
  • Van Neste M, et al. 2025. Clopidogrel transfer into human milk: case series – a contribution from the ConcePTION project. Front Pharmacol. 16:1499243.  

 

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