MotherToBaby

Medications and More during pregnancy and breastfeeding

Search

866.626.6847

Ibuprofen

Selected References

  • Bird TM, et al. 2009. Demographic and environmental risk factors for gastroschisis and omphalocele in the National Birth Defects Prevention Study. J Ped Surg 44(:1546-1551.
  • Brandlistuen RE et al. 2013. Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled study. Int J Epidemiol 42:1702-1713.
  • Dawood MY. 1993. Nonsteroidal anti-inflammatory drugs and reproduction. Am J Obstet Gynecol 169(:1255-1265.
  • Daniel S, et al. 2014. Fetal exposure to nonsteroidal anti-inflammatory drugs and spontaneous abortion. Can Med Assoc J 186(5): E177-E182.
  • Daniel S, et al. 2015. NSAIDs and spontaneous abortions – true effect or an indication bias? Br J Clin Pharmacol. 80(4):750-4.
  • Dathe K, et al. 2018. No evidence of adverse pregnancy outcome after exposure to ibuprofen in the first trimester—Evaluation of the national Embryotox cohort. Reproductive Toxicology 79: 32-38.
  • Ericson A and Kallen BA. 2001. Nonsteroidal anti-inflammatory drugs in early pregnancy. Reprod Toxicol 15:371- 375.
  • 2020. FDA Warns that Using a Type of Pain and Fever Medication in Second Half of Pregnancy Could Lead to Complications. https://www.fda.gov/news-events/press-announcements/fda-warns-using-type-pain-and-fever-medication-second-half-pregnancy-could-lead-complications?utm_medium=email&utm_source=govdelivery
  • Hernandez RK, et al. 2012; Nonsteroidal anti-inflammatory drug use among women and the risk of birth defects. Am J Obstet Gynecol 206:228.e1-8.
  • Kavoussi PK, Gilkey MS, Hunn C, Luke Machen G, Chen SH, David Wininger J, Kavoussi KM, Kavoussi SK. 2018. Ibuprofen does not have an adverse impact on semen parameters. J Assist Reprod Genet 35(12): 2201-2204.
  • Killick S and Elstein M. 1987. Pharmacological production of luteinized unruptured follicles by prostaglandin synthetase inhibitors. Fertil Steril 47:773-777.
  • Kristensen DM, et al. 2018. Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism. PNAS.
  • Janssen NM and Genta MS. 2000. The effects of immunosuppressive and anti-inflammatory medication on fertility, pregnancy, and lactation. Arch Intern Med 160:610-619.
  • Li DK, et al. 2003. Exposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage: population based cohort study. BMJ 327:368.
  • McInerney KA, et al. 2017. Preconception use of pain-relievers and time-to-pregnancy: a prospective cohort study. Hum Reprod. 32(1):103-111.
  • Nakhai-Pour HR et al. 2011. Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion. CMAJ 183:1713-1720.
  • Nezvalova-Henriksen K et al. 2013. Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective study. BJOG 120:948-959.
  • Nielsen GL, et al. 2001. Risk of adverse birth outcome and miscarriage in pregnant users of non-steroidal anti-inflammatory drugs: population based observational study and case-control study. BMJ 322:266-270.
  • Nielsen GL, et al. 2004. Danish group reanalyses miscarriage in NSAID users. BMJ 328:109.
  • 2020. Can I take ibuprofen when I’m pregnant? https://www.nhs.uk/common-health-questions/pregnancy/can-i-take-ibuprofen-when-i-am-pregnant/#:~:text=It’s%20best%20to%20avoid%20taking,risk%20of%20complications%2C%20including%20miscarriage.
  • Ofori B, et al. 2006. Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: a nested case-control study. Birth Defects Res B Dev Reprod Toxicol 77:268-279.
  • Penfield M, et al. 2019. Ibuprofen and Postpartum Blood Pressure in Women With Hypertensive Disorders of Pregnancy A Randomized Controlled Trial. Obstet Gynecol. 134(6):1219-1226.
  • Petersen TG, et al. 2018. Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child. Int J Epidemiol 47(1):121-130.
  • Rigourd V et al. 2014. Ibuprofen concentrations in human mature milk – First data about pharmacokinetics study in breast milk with AOR-10127 “Antalait” study. Ther Drug Monitor. 36:590-6.
  • Torfs CP, et al. 1996. Maternal medications and environmental exposures as risk factors for gastroschisis. Teratology 54:84-92.
  • Triebwasser JE, et al. 2019. A randomized-controlled trial to assess the effect of ibuprofen on postpartum blood pressure in women with hypertensive disorders of pregnancy. Pregnancy Hypertens. 18:117-121.
  • Townsend RJ, et al. 1984. Excretion of ibuprofen into breast milk. Am J Obstet Gynecol. 149:184-186.
  • Uhler ML, et al. 2001. The effect of nonsteroidal anti-inflammatory drugs on ovulation: a prospective, randomized clinical trial. Fertil Steril 76:957-961.