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MotherToBaby

Medications and More during pregnancy and breastfeeding

Low Dose Aspirin

Selected References:

  • Abdi N, et al. 2020. The effect of aspirin on preeclampsia, intrauterine growth restriction and preterm delivery among healthy pregnancies with a history of preeclampsia. J Chin Med Assoc, 83(9):852-857. 
  • Alsulami FT, Hamed EM. 2026. Early initiation of low-dose aspirin for the prevention of pre-eclampsia in high-risk pregnancies. Scientific reports, 16(1):1761. 
  • American College of Obstetricians and Gynecologists. 2018. Low-dose aspirin use during pregnancy (Committee Opinion No. 743). Obstetrics & Gynecology, 132(1):e44–e52. 
  • American College of Obstetricians and Gynecologists. 2021. Low-dose aspirin use for the prevention of preeclampsia and related morbidity and mortality (Practice Advisory). Available from: https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2021/12/low-dose-aspirin-use-for-the-prevention-of-preeclampsia-and-related-morbidity-and-mortality  
  • Bloor M, Paech M. 2013. Nonsteroidal anti-inflammatory drugs during pregnancy and the initiation of lactation. Anesth Analg, 116(5):1063-75. 
  • Bujold E, et al. 2026. The effect of aspirin on the risk of preeclampsia based on the Fetal Medicine Foundation first-trimester risk. American journal of obstetrics and gynecology, 234(3):770–778. 
  • Datta P, et al. 2017. Transfer of low-dose aspirin into human milk. J Hum Lact, 33(2):296-299.  
  • Ellfolk M, Hultzsch S. 2015. Analgesics, antiphlogistics and anesthetics. In C Schaefer, P Peters, R Miller (Eds.), Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment. 3rd ed. 653-655. London: Elsevier. 
  • Grab D, et al. 2000. Effects of low-dose aspirin on uterine and fetal blood flow during pregnancy: results of a randomized, placebo-controlled, double-blind trial. Ultrasound Obstet Gynecol, 15:19-27.  
  • Hoffman MK, et al. 2024. Neurodevelopment of children whose mothers were randomized to low-dose aspirin during pregnancy. Obstet Gynecol, 1:1-8. 
  • Kupka E, et al. 2023. Low-dose aspirin use in pregnancy and the risk of preterm birth: a Swedish register-based cohort study. Am J Obstet Gynecol, 228(3):336e1-336e9. 
  • Maher JE, et al. 1993. The effect of low-dose aspirin on fetal urine output and amniotic fluid volume. Am J Obstet Gynecol 169:885-8.  
  • Malm H, Borish C. 2015. Analgesics, non-steroidal anti-inflammatory drugs (NSAIDS), muscle relaxants, and antigout medications. In C Schaefer, P Peters, R Miller (Eds.), Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment, 3rd ed. 27-32. London: Elsevier. 
  • Marret S, et al. 2010. Prenatal Low-Dose Aspirin and Neurobehavioral Outcomes of Children Born Very Preterm. Pediatrics, 125(1):e29-e34. 
  • Martini A, et al. 2003. Analysis of semen from patients chronically treated with low or moderate doses of aspirin-like drugs. Fertil and Steril, 80(1):221-222. 
  • Mone F, McAuliffe FM. 2015. Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomized trial. Ir Med J, 08(1):5. 
  • Naimi A, et al. 2021. The Effect of Preconception-Initiated Low-Dose Aspirin on Human Chorionic Gonadotropin Detected Pregnancy, Pregnancy Loss, and Live Birth. Annals of Internal Medicine, 174(5):595-601. 
  • Ngcobo NM, et al. 2026. The impact of low-dose aspirin on hemoglobin levels in pregnancy: A secondary analysis of a randomized controlled trial for prevention of hypertensive disorders of pregnancy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 173(2):982–988. 
  • Ostensen M, et al. 2006. Anti-inflammatory and immunosuppressive drugs and reproduction. Arthritis Res Ther, 8(3):1-19. 
  • Rolnik DL, et al. 2025. Aspirin, Birthweight, and Large-For-Gestational-Age Neonates: A Secondary Analysis of the ASPRE Trial. BJOG: an international journal of obstetrics and gynaecology, 132(11):1606–1614. 
  • Rolnik DL, et al. & ASPRE and SPREE Collaborators. 2026. Combined impact of first-trimester risk and aspirin adherence on preterm preeclampsia prevention. American journal of obstetrics and gynecology, S0002-9378(26)00078-5. 
  • Schisterman EF, et al. 2015. Preconception low-dose aspirin and time to pregnancy: findings from the effects of aspirin in gestation and reproduction randomized trial. J Clin Endocrinol Metab, 100(5):1785-91. 
  • Sohail H. 2025. Prophylaxis of Preeclampsia With Low-Dose Aspirin: A Comprehensive Review. Cureus, 17(11): e96529. 
  • Spigset O, et al. 2000. Analgesics and breast-feeding: safety considerations.  Paediatr Drugs, 2(3):223-38. 
  • US Preventive Services Task Force, et al. 2021. Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: US Preventive Services Task Force Recommendation Statement. JAMA, 326(12):1186–1191.

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