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MotherToBaby

Medications and More during pregnancy and breastfeeding

Miconazole

Selected References:

  • Bender EA, et al. 2021. Treatment methods for vulvovaginal candidiasis in pregnancy. J Mycol Med. 31(3):101138.  
  • Butler DC, et al. 2014. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 70(3):417 e1-10.  
  • Carter TC, et al. 2008. Antifungal drugs and the risk of selected birth defects. Am J Obstet Gynecol. 198:191-193.  
  • Czeizel AE, et al. 2004. Population-based case-control teratologic study of topical miconazole. Congenit Anom. 44(1):41-45.  
  • Daniel S, et al. 2018. Vaginal antimycotics and the risk for spontaneous abortions. Am J Obstet Gynecol. 218(6):601.e1-601.e7. 
  • Giavini E, et al. 2010. Are azole fungicides a teratogenic risk for human conceptus? Toxicol Lett. 198(2):106-111.  
  • Kazy Z, et al. 2005. The possible association between the combination of vaginal metronidazole and miconazole treatment and poly-syndactyly population-based case-control teratologic study. Reprod Toxicol. 20(1):89-94.  
  • Maftei NM, et al. 2023. Vulvovaginal Candidiasis in Pregnancy-Between Sensitivity and Resistance to Antimycotics. J Xenobiot. 13(3):312-322.  
  • Mendling W, et al. 2012. Guidelines vulvovaginal candidosis (2010) of the German Society for Gynecology and Obstetrics, the Working Group for Infections and Infectimmunology in Gynecology and Obstetrics, the German Society of Dermatology, the Board of German Dermatologists and German speaking Mycological Society. Mycoses. Jul:(55) Suppl 3:1-13. 
  • Murase JE, et al. 2014. Safety of dermatologic medications in pregnancy and lactation: Part 1 Pregnancy. J Am Acad Dermatol. 70(3):401.e1-14.  
  • Patel VM, et al. 2017. Topical antiviral and antifungal medications in pregnancy: a review of safety profiles. J Eur Acad Dermatol Venereol. 31(9):1440-1446. 
  • Rotem R, et al. 2018. Risk of major congenital malformations following first-trimester exposure to vaginal azoles used for treating vulvovaginal candidiasis: a population-based retrospective cohort study. BJOG. 125(12):1550-1556.  
  • Stevens RE, et al. 2002. Bioavailability study of a 1200 mg miconazole nitrate vaginal ovule in healthy female adults. J Clin Pharmacol. 42(1):52-60.  
  • Tiboni GM, et al. 2008. Teratogenic effects in mouse fetuses subjected to the concurrent in utero exposure to miconazole and metronidazole. Reprod Toxicol. 26(3-4):254-261.  

 

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