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Nirmatrelvir/Ritonavir (Paxlovid®)

December 1, 2022

Selected References:

  • American College of Obstetricians and Gynecologists (ACOG). 2022.Covid-19 faqs for obstetrician-gynecologists, obstetrics. Retrieved September 1, 2022, from https://www.acog.org/clinical-inforation/physician-faqs/covid-19-faqs-for-ob-gyns-obstetrics.
  • Corbett AH, Kayira D, White NR, et al. Antiretroviral pharmacokinetics in mothers and breastfeeding infants from 6 to 24 weeks post-partum: Results of the BAN Study. Antivir Ther. 2014;19:587–95.
  • Gandhi M, Mwesigwa J, Aweeka F, et al. Hair and plasma data show that lopinavir, ritonavir, and efavirenz all transfer from mother to infant in utero, but only efavirenz transfers via breastfeeding. J Acquir Immune Defic Syndr. 2013;63:578–84.
  • Palombi L, Pirillo MF, Andreotti M, et al. Antiretroviral prophylaxis for breastfeeding transmission in Malawi: drug concentrations, virological efficacy and safety. Antivir Ther. 2012;17:1511–9. [PubMed]
  • Pfizer Laboratories Div Pfizer Inc. 2022. Paxlovid fact sheet for healthcare providers: Emergency use authorization for PaxlovidTM. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=7bdddfba-bd31-44cb-ba9e-23a4e17a4691&type=display
  • Ramírez-Ramírez A, Sanchez-Serrano E, Loaiza-Flores G, et al. Simultaneous quantification of four antiretroviral drugs in breast milk samples from HIV-positive women by an ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method. PLoS One. 2018;13:e0191236.
  • Rezk NL, White N, Bridges AS, et al. Studies on antiretroviral drug concentrations in breast milk: Validation of a liquid chromatography-tandem mass spectrometric method for the determination of 7 anti-human immunodeficiency virus medications. Ther Drug Monit. 2008;30:611–9.

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