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Tetanus, Diphtheria and Pertussis (Tdap) Vaccine

April 1, 2018

Selected References:

  • ACOG Committee Opinion No. 718: Update on immunization and pregnancy: tetanus, diphtheria, and pertussis vaccination. 2017. Obstet Gynecol. 130(3):668-669
  • Baxter R, et al. 2017. Effectiveness of vaccination during pregnancy to prevent infant pertussis. Pediatrics; 139(5):e2016409.1
  • Updated Recommendations for Use of Tetanus Toxoid, Reduced Diphtheria, and Acellular Pertussis Vaccine (Tdap) in Pregnant Women – Advisory Committee on Immunization Practices (ACIP), 2012. MMWR. 2013;62(07):131-5.
  • Campbell H, et al. (2018). Review of vaccination in pregnancy to prevent pertussis in early infancy. J Med Microbiol, 67(10), 1426-1456.
  • DeSilva M, et al. 2016. Tdap vaccination during pregnancy and microcephaly and other structural birth defects in offspring. JAMA 316(17): 1823-1825.
  • Havers FP, et al. (2020). Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccines: Updated Recommendations of the Advisory Committee on Immunization Practices – United States, 2019. MMWR Morb Mortal Wkly Rep, 69(3): 77-83.
  • Kharbanda EO, et al. 2014. Evaluation of the association of maternal pertussis vaccination with obstetric events and birth outcomes. JAMA 312(18):1897-1904.
  • Khromava A et al. 2008. Immunization of pregnant women with tetanus-diphtheria-acellular pertussis (Tdap) vaccine: 29 months of data from the ADACEL vaccine pregnancy registry. Pharmacoepidemiol Drug Saf. Vol. 17(1): S194-S195.
  • Layton JB, et al. 2017. Prenatal Tdap immunization and risk of maternal and newborn adverse events. Vaccine pii: S0264-410X(17)30868-X.
  • McMillan M, et al. 2017. Safety of tetanus diphtheria, and pertussis vaccination during pregnancy: a systematic review. Obstet Gynecol 129(3): 560-573.
  • Mooi FR and de Greeff SC. 2007. The case for maternal vaccination against pertussis. Lancet Infect Dis 7(9):614-624.
  • Morgan JL et al. 2015. Pregnancy outcomes after antepartum tetanus, diphtheria, and acellular pertussis vaccination. Obstet Gynecol 125: 1433-1438.
  • Munoz FM et al. 2014. Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial. 2014 311(17):1760-9.
  • Nasser, R et al. (2019). Are all vaccines safe for the pregnant traveler? A systematic review and meta- analysis. J Travel Med. doi:10.1093/jtm/taz074
  • National Center for Immunization and Respiratory Diseases. General recommendations on immunization — recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2011;60 (RR02):1-60.
  • Shakib et al. 2013. Tetanus, Diphtheria, Acellular Pertussis Vaccine during Pregnancy: Pregnancy and Infant Health Outcomes. J Pediatr. pii: S0022-3476(13)00734-8.
  • Sukumaran L et al. 2015. Association of Tdap vaccination with acute events and adverse birth outcomes among pregnant women with prior tetanus-containing immunizations. JAMA 20;314(15):1581-7.
  • Sukumaran L et al. 2015. Safety of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis and Influenza Vaccinations in Pregnancy. Obstet Gynecol. 126(5):1069-74.
  • Walls T et al. 2016. Infant outcomes after exposure to Tdap vaccine in pregnancy: an observational study. BMJ Open 6(1):e009536.
  • Winter K et al. 2012. California pertussis epidemic, 2010. The Journal of Pediatrics, Volume 161, Issue 6, pp 1091-1096.
  • Zheteyeva YA et al. 2012. Adverse event reports after tetanus toxoid reduced diphtheria toxoid and acellular pertussis vaccines in pregnant women. Am J Obstet Gynecol Volume 207, Issue 1, pp 59.e1-59.e7.
  • Zimmermann, P et al. (2019). The Effect of Maternal Immunization During Pregnancy on Infant Vaccine Responses. EClinicalMedicine, 13: 21-30.

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