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MotherToBaby

Medications and More during pregnancy and breastfeeding

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Ciprofloxacin

Selected References:

  • AAP Committee on Drugs. 2001. The transfer of drugs and other chemicals into human milk. Pediatrics 108:776-789.
  • Acar S, et al. 2019. Pregnancy outcomes following quinolone and fluoroquinolone exposure during pregnancy: A systematic review and meta-analysis. Reprod Toxicol 85:65-74.
  • ACOG Committee Opinion. 2002. Management of asymptomatic pregnant or lactating women exposed to anthrax. Int J Gynecol Obstet 77:293-295.
  • Berkovitch M, et al. 1994. Safety of the new quinolones in pregnancy. Obstet Gynecol 84(4):535-538.
  • Bomford JAL, et al. 1993. Ciprofloxacin use during pregnancy. Drugs 45(S3): 461-462.
  • Gardner D, et al. 1992. Simultaneous concentrations of ciprofloxacin in breast milk and in serum in mother and breast-fed infant. Clin Pharm 11:352-354.
  • Kabeya CM, et al. 1995. Ciprofloxacin for multiresistant enteric fever in pregnancy. The Lancet 346:307-308.
  • Leung D, et al. 1995. Treatment of typhoid in pregnancy. The Lancet 346:648.
  • Loebstein R, et al. 1998. Pregnancy outcome following gestational exposure to fluoroquinolones: a multicenter prospective controlled study. Antimicrob Agents Chemother 42(6):1336-1339.
  • Meaney-Delman D, et al. 2013 Prophylaxis and treatment of anthrax in pregnant women. Obstet Gynecol. 122(4):885-900
  • Nahum G, et al. 2006. Antibiotic use in pregnancy and lactation. Obstet Gynecol 107(5):1120-1138.
  • Padberg S, Wacker E, et al. 2014. Observational cohort study of pregnancy outcomes after first-trimester exposure to fluoroquinolones. Antimicrob. Agents Chemother. 58(8): 4392-4398.
  • Polacheck H, et al. 2005. Transfer of ciprofloxacin, ofloxacin and levofloxacin across the perfused human placenta in vitro. Eur J Obstet Gynecol 122:61-65.
  • Schaefer C, et al. 1996. Pregnancy outcome after prenatal quinolone exposure: evaluation of a case registry of the European Network of Teratology Information Services (ENTIS). Eur J Obstet Gynecol 69:83-89.
  • Schluter G. 1989. Ciprofloxacin: toxicologic evaluation of additional safety data. The Am J Med 87(5A):S37-S39.
  • Stahlmann R, et al. 1998. Chondrotoxicity and toxicokinetics of sparfloxacin in juvenile rats. Antimicrob Agents Chemother 42(6):1470-1475.
  • Van Wattum JJ, et al. 2019. Antibiotics and lactation: An overview of relative infant doses and a systematic assessment of clinical studies. Basic Clin Pharmacol Toxicol 124(1):5-17.
  • Yefet E, et al. 2018. The safetyof quinolones and fluoroquinolones in pregnancy: a meta-analysis. doi: 10.1111/1471-0528.15119.