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Nefazodone (Serzone®)

August 1, 2023

Selected References:

  • Dodd S, et al. 1999. Determination of nefazodone and its pharmacologically active metabolites in human blood and breast milk by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl;730:249-55.
  • Dodd S, et al 2000. Nefazodone in the breast milk of nursing mothers: a report of two patients. J Clin Psychopharmacol; 20:717-8.
  • Einarson A, et al. 2003. A multicentre prospective controlled study to determine the safety of trazodone and nefazodone use during pregnancy. Can J Psychiatry 48(2):106-110.
  • Einarson A, et al. 2009. Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study. Can J Psychiatry 54(4):242 246.
  • Food and Drug Administration 2014. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/076037s011lbl.pdf [Accessed 7/2023].
  • Khazaie H, et al. 2013. Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial. Psychiatry Res. 210(3):901-5.
  • Rivett KF & Barcelona PS. 1974. Toxicology of trazodone. Mod Probl Pharmacopsychiatry 9:76-86.
  • Verbeeck RK, et al. 1986. Excretion of trazodone in breast milk. Br J Clin Pharmacol. 22(3):367-370.
  • Yapp P, et al. 2000. Drowsiness and poor feeding in a breast-fed infant: association with nefazodone and its metabolites. Ann Pharmacother 34(11):1269-1272.
  • Yaris F, et al. 2004. Newer antidepressants in pregnancy: prospective outcome of a case series. Reprod Toxicol; 19:235-238.

 

National Pregnancy Registry for Psychiatric Medications: There is a pregnancy registry for people who take psychiatric medications, such as nefazodone. For more information you can look at their website: https://womensmentalhealth.org/research/pregnancyregistry/

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