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MotherToBaby

Medications and More during pregnancy and breastfeeding

Olanzapine (Zyprexa®)

Selected References:

  • Ambresin G, et al. 2004. Olanzapine excretion into breast milk: a case report. J Clin Psychopharmacol; 24(1):93-95. 
  • Aydin B, et al. 2015. Olanzapine and quetiapine use during breastfeeding: Excretion into breast milk and safe breastfeeding strategy. J Clin Psychopharmacol; 35:206-208. 
  • Betcher HK, et. al 2020. Psychotropic Treatment During Pregnancy: Research Synthesis and Clinical Care Principles. J Womens Health 29(3):310-318. 
  • Brunner E, et al. 2013. Olanzapine in pregnancy and breastfeeding: a review of data from global safety surveillance. BMC Pharmacology & Toxicology, 14, 1-8.  
  • Croke S, et al. 2003. Olanzapine excretion in human breast milk: estimation of infant exposure. Int J Neuropsychopharmacol; 5:243-247. 
  • Damkier P, et al. 2018. The safety of second-generation antipsychotics during pregnancy: a clinically-focused review. CNS Drugs 32:351-366. 
  • Einarson A & Boskovic R. 2009. Use and safety of antipsychotics during pregnancy. Journal of Psychiatric Practice; 15, 183-192.  
  • Eli Lilly and Company. 2025. Zyprexa product label. Available at: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d5051fbc-846b-4946-82df-341fb1216341. Accessed 31 March 2026.  
  • Ellfolk M, et al. 2021. Second-generation antipsychotic use during pregnancy and risk of congenital malformations. Eur J Clin Pharmacol. 2021; 77(11): 1737–1745. 
  • Ennis ZN, et al. 2014. Pregnancy exposure to Olanzapine, quetiapine, risperidone, aripiprazole and risk of congenital malformations: A systemic review.  Basic & Clinical Pharmacology & Toxicology; 116(4), 315-320.   
  • Friedman SH, et al. 2017. Atypical antipsychotic use and outcomes in an urban maternal mental health service. Int J Psychiatry Med; 51(6): 521-533. 
  • Gilad O, et al. 2011. Outcome of infants exposed to olanzapine during breastfeeding. Breastfeeding Medicine; 6, 55-58. 
  • Habermann F, et al. 2013. Atypical antipsychotic drugs and pregnancy outcome: a prospective, cohort study. J Clin Psychopharmacol; 33(4):453-462.  
  • Heinonen E, et al. 2022. Antipsychotic Use During Pregnancy and Risk for Gestational Diabetes: A National Register‑Based Cohort Study in Sweden. CNS Drugs; 36:529-
  • 539. Huybrechts KF, et al. 2016. Antipsychotic use in pregnancy and the risk for congenital malformations. JAMA Psychiatr; 73(9):938-946. 
  • Johnson KC et al. 2012. Prenatal antipsychotic exposure and neuromotor performance during infancy.  Arch Gen Psychiatry; 69(8):787-794. Kallen B, et al. 2013. The use of central nervous system active drugs during pregnancy.  Pharmaceuticals. 6(10): 1221-1286. 
  • Kolli P, et al. 2023. Olanzapine Pharmacokinetics: A Clinical Review of Current Insights and Remaining Questions. Pharmgenomics Pers Med; 16:1097-1108. 
  • Manouilenko I, et al. 2018. Long-acting olanzapine injection during pregnancy and breastfeeding: a case report. Arch Womens Ment Health; 21(5):587-589 
  • McKenna K, et al. 2005. Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative study. Journal of Clinical Psychiatry; 4, 444-449.  
  • Miller DE, Sebastian CS. 2005. Olanzapine-induced hyperprolactinemia and galactorrhea reversed with addition of bromocriptine: a case report. J Clin Psychiat; 66:269-270. 
  • Newport DJ, et al 2007. Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes. Am J Psychiatry; 164(8):1214-20.  
  • Pacchiarotti I, et al. 2016. Mood stabilizers and antipsychotics during breastfeeding: Focus on bipolar disorder. Eur Neuropsychopharmacol; 26:1562-1578. 
  • Park Y, et al. 2018. Continuation of atypical antipsychotic medication during early pregnancy and the risk of gestational diabetes. Psychiatry; 175(6):564-574. 
  • Reutfors J, et al. 2020 Antipsychotic drug use in pregnancy: A multinational study from 10 countries. Schizophr Res; 220:106-115. 
  • Rubakowski J, et al. 2019. Recommendations of the Poliksh Psychiatric Association regarding the treatment of affective disorders in women of childbearing age. Part II: Bipolar disorder. Psychiatr Pol; 53(2):263-276. 
  • Shao P, et al. 2015. Effects of Clozapine and other Atypical Antipsychotics on Infants Development Who Were Exposed to as Fetus: A Post-Hoc Analysis. PLoS One; 10(4). 
  • Teodorescu A, et al. 2017. Dilemma of treating schizophrenia during pregnancy: a case series and a review of literature. BMC Psychiatry; 17(1):311.  
  • Vigod SN, et al. 2015. Antipsychotic drug use in pregnancy: high dimensional, propensity matched, population based cohort study. BMJ; 350:h2298.  

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