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Vitamin K

February 1, 2025

Selected References:

  • Bhoj E, et al. 2013. Late-onset partial complex seizures secondary to cortical dysplasia in a patient with maternal vitamin K deficient embryopathy: comments on the article by Toriello et al. [2013] and first report of the natural history. Am J Med Genet A. 161(9):2396-2398.
  • Dickson RC, et al. 1994. Antenatal vitamin K therapy of the low-birth-weight infant. Am J Obstet Gynecol 170:85-89.
  • Eventov-Friedman S, et al. 2009. Third trimester fetal intracranial hemorrhage owing to vitamin K deficiency associated with hyperemesis gravidarum. J Pediatr Hematol Oncol. 31(12):985-988.
  • Goto T, et al. 2018. A rare case of fetal extensive intracranial hemorrhage and whole-cerebral hypoplasia due to latent maternal vitamin K deficiency. J Neonatal Perinatal Med 11(2): 191-194.
  • Kawamura Y, et al. 2008. Vitamin K deficiency in hyperemesis gravidarum as a potential cause of fetal intracranial hemorrhage and hydrocephalus. Prenat Diagn. 28(1):59-61.
  • Kazzi NJ, et al. 1989. Maternal administration of vitamin K does not improve the coagulation profile of preterm infants. Pediatrics 84:1045-1050.
  • Klebanoff MA, et al. 1993. The risk of childhood cancer after neonatal exposure to vitamin K. N Engl J Med 329: 905-908.
  • Lee S, et al. 2022. Fetal intracranial hemorrhage and maternal vitamin K deficiency induced by total parenteral nutrition: A case report. Medicine (Baltimore). 101(1):e28434.
  • Morales WJ, et al. 1988. The use of antenatal vitamin K in the prevention of early neonatal intraventricular hemorrhage. Am J Obstet Gynecol 159:774-779.
  • Njisten K, et al. 2022. Hyperemesis gravidarum and vitamin K deficiency: a systematic review. Br J Nutr 128(1):30-42.
  • Pomerance JJ, et al. 1987. Maternally administered antenatal vitamin K1: effects on neonatal prothrombin activity, partial thromboplastin time, and intraventricular hemorrhage. Obstet Gynecol 70:235-241.
  • Robinson JN, et al. 1998. Coagulopathy secondary to vitamin K deficiency in hyperemesis gravidarum. Obstet Gynecol 92:673-675.
  • Roman E, et al. 2002. Vitamin K and childhood cancer: analysis of individual patient data from six case-control studies. Br J Cancer 86:63-69.
  • Sotodate G, et al. 2019. Fetal intracranial hemorrhage due to maternal subclinical vitamin K deficiency associated with long-term eating disorder. J Obstet Gynaecol Res. 2019 Feb;45(2):461-465.
  • Toriello HV, et al. 2013. Maternal vitamin K deficient embryopathy: association with hyperemesis gravidarum and Crohn disease. Am J Med Genet A. 161A(3):417-429.
  • Yasuda K, et al. 2023. Intrauterine fetal death due to fetal intracranial hemorrhage associated with maternal vitamin K deficiency: A case report. Case Rep Womens Health 40: e00566.

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