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MotherToBaby

Medications and More during pregnancy and breastfeeding

Topical Tretinoin

Selected References:

  • Camera G and Pregliasco P. 1992. Ear malformation in baby born to mother using isotretinoin cream. Lancet, 339:687.
  • De Wals P. et al. 1991. Association between holoprosencephaly and exposure to topical retinoids: results of the EUROCAT survey. Paediatr Perinat Epidemiol, 5:445-447.
  • Jick S, et al. 1993. First trimester topical tretinoin and congenital disorders. Lancet, 341:1181-1182.
  • Kaplan YC, et al. 2015. Pregnancy outcomes following first-trimester exposure to topical retinoids: A systematic review and meta-analysis. Br J Dematol, 173:1132-1141.
  • Loureiro KD, et al. 2005. Minor malformations characteristic of the retinoic acid embryopathy and other birth outcomes in children of women exposed to topical tretinoin during early pregnancy. American Journal of Medical Genetics, 136A:117-121.
  • Lipson AH, et al. 1993. Multiple congenital defects associated with maternal use of topical tretinoin. Lancet, 341:1352-1353.
  • MacDonald SC, et al. 2019. Identifying pregnancies in insurance claims data: Methods and application to retinoid teratogenic surveillance. Pharmacoepidemiol Drug Saf 28(9):1211-1221.
  • Panchaud A, et al. 2012. Pregnancy outcome following exposure to topical retinoids: a multicenter prospective study. J Clin Pharmacol, 52:1844-1851.
  • Ross SA, et al. 2000. Retinoids in embryonal development. Physiol Rev, 80(3):1021-1054.
  • Selcen D, et al. 2000. Otocerebral anomalies associated with topical tretinoin use. Brain Dev 22:218-220.
  • Shapiro L, et al. 1997. Safety of first trimester exposure to topical tretinoin: prospective cohort study. Lancet, 350:1143-1144.
  • Veraldi S, et al. 2016. Are topical retinoids teratogenic? G Ital Dermatol Venereol. 151(6):700-705.
  • Williams AL et al. 2020. Teratogen update: Topical use and third-generation retinoids. Birth Defects Res, 112(15):1105-1114.