MotherToBaby

Medications and More during pregnancy and breastfeeding

Search

866.626.6847

Baclofen

Selected References:

  • Ali Sakr Esa W, et al. 2009. Epidural analgesia in labor for a woman with an intrathecal baclofen pump. Int J Obstet Anesth. 2009 Jan;18(1):64-6.  
  • Andrade C. 2020. Individualized, High-Dose Baclofen for Reduction in Alcohol Intake in Persons With High Levels of Consumption, J Clin Psychiatry. Aug 4;81(4):20f13606. 
  • Baclofen Product Label. 2023: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=04dac0f6-cc6c-4959-9bca-a6e4a99690f3. Accessed 11/2024. 
  • Balakirouchenane D, et al. 2021. Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report. Neonatology; 118(5):624-627.   
  • Barker KDD, et al. 2025. Three consecutive pregnancies in a woman with spastic cerebral palsy being treated with intrathecal baclofen therapy. Int J Gynaecol Obstet;168(3):893-895.  
  • Bernard N, et al. 2012. Pregnancy outcomes after in utero exposure to baclofen. Reprod Toxicol; 34(2):157. 
  • Briggs, GG and Freeman RK. 2016. Drugs in Pregnancy and Lactation, Tenth Edition; Wolters Kluwer. 122-3. 
  • Dalton CM, et al. 2008. The safety of baclofen in pregnancy: intrathecal therapy in multiple sclerosis. Mult Scler; 14(4):571-2. 
  • Delhaas EM, Verhagen J. 1992. Pregnancy in a quadriplegic patient treated with continuous intrathecal baclofen infusion to manage her severe spasticity. Case report. Paraplegia; 30: 527-8. 
  • Engrand N, et al. 2001. Intrathecal baclofen for severe tetanus in a pregnant woman. Eur J Anaesthesiol; 18:261-3. 
  • Eriksson G, Swahn CG. 1981. Concentrations of baclofen in serum and breast milk from a lactating woman. Scand J Clin Lab Invest; 41(2):185-7.  
  • Freeman, EH and Delaney, RM. 2016. Neonatal Baclofen Withdrawal: A Case Report of an Infant Presenting with Severe Feeding Difficulties.J Pediatr Nurs. May-Jun: 31(3):346-9.  
  • Goldkamp J, et al. 2011. Stiff person syndrome and pregnancy. Obstet Gynecol; 118(2 Pt 2):454-457.   
  • Hale TW and Rowe HE. 2015. Medications and Mother’s Milk 2017. Springer Publishing Co. 93-4. 
  • Hara T, et al. 2018. Pregnancy and breastfeeding during intrathecal baclofen therapy – A case study and review. NMC Case Rep J. Jun 25;5(3):65-8. 
  • Hyser, CL and Drake, ME. 1984. Status Epilepticus after Baclofen Withdrawal. J Natl Med Assoc; 76(5):533, 537-8.  
  • Lin HH, et al. 2014. Baclofen distribution into breast milk-a potential for toxicity? J Med Toxicol; 10:86.  
  • Lin HH, et al. 2014. Prevention of neonatal abstinence syndrome in the setting of intrauterine baclofen exposure. J Med Toxicol; 10:85-6.   
  • Logge WB, et al. 2020. Baclofen modulates cardiovascular responses to appetitive cues in treatment-seeking alcohol use disorder individuals. Hum Psychopharmacol. Mar;35(2):e2722. 
  • Mahdavinasab SM, et al. 2019. Baclofen as an adjuvant therapy for autism: a randomized, double-blind, placebo-controlled trial. Eur Child Adolesc Psychiatry. Dec;28(12):1619-1628. 
  • Mendez-Lucena C, et al. 2014. Intrathecal baclofen for dystonia treatment during pregnancy: A case report. Neurologia; 31(2): 131-132. 
  • Moran LR, et al. 2004. Intrauterine Baclofen Exposure: A Multidisciplinary Approach. Pediatrics; 114(2): e267-8. 
  • Morton CM, et al. 2009. Intrathecal baclofen administration during pregnancy: a case series and focused clinical review. PM R. Nov;1(11):1025-9.  
  • Mousigian MA, et al. 2022. Neonatal baclofen withdrawal following intrauterine exposure. J Pediatr Rehabil Med; 15(2):389-394. 
  • Muñoz FC et al. 2020. Pregnancy outcome in a woman exposed to continuos intrathecal baclofen unfusion. Ann Pharmacother. Jul-Aug 2000;34(7-8):956 
  • Ratnayaka BD, et al. 2001. Drug points: Neonatal convulsions after withdrawal of baclofen. BMJ. Jul 14;323(7304):85.  
  • Roberts AG, et al. 2003. Intrathecal baclofen pump implantation during pregnancy. Neurology; 61:1156-7. 
  • Weatherby SJ, et al. 2004. Pregnancy in stiff-limb syndrome. Mov Disord; 19(7):852-4. 
  • Yang K, et al. 2024. Intrathecal baclofen pump in pregnancy: case report, literature review, and management considerations. Reg Anesth Pain Med; 49(12):919-922. 

This website is supported by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) as part of an award totaling $6,000,000 with zero percentage financed with non-governmental sources. The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement by, HRSA, HHS, or the U.S. Government.