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Cetirizine (Zyrtec®)

Selected References:

  • Ahmed E, Abdel-Emam R. 2019. The potential impact of 1st and 2nd generation antihistamines on male fertility. Comp Clin Pathol, 28, 1465–1470.
  • Einarson A, et al. 1997. Prospective controlled study of hydroxyzine and cetirizine in pregnancy. Annals of Allergy, Asthma & Immunology, 78, 183-186.
  • Etwel F, et al. 2014. The fetal safety of cetirizine: an observational cohort study and meta-analysis. Journal of Obstetrics and Gynaecology. 34(5):392-9.
  • Gilbert C, et al. 2005. Fetal safety of drugs used in the treatment of allergic rhinitis. Drug Safety, 28(8), 707-719.
  • Andersson N, et al. 2020. Association Between Fexofenadine Use During Pregnancy and Fetal Outcomes. JAMA Pediatr. 174(8):e201316.
  • Gilboa S, et al. & The National Birth Defects Prevention Study. 2009. Use of antihistamine medications during early pregnancy and isolated major malformations. Birth Defects Research Part A: Clinical and Molecular Teratology, 85, 137-150.
  • Golembesky A, et al. 2018. Safety of cetirizine in pregnancy. Journal of Obstetrics and Gynaecology,22,1-6.
  • Hayashi T, et al. 2006. Asthenospermia in hay fever patients improved by stopping treatment with histamine H1 receptor antagonists. International Journal of Urology.13(7):1028-30.
  • Powell R, et al. 2007. BSACI guidelines for the management of chronic urticaria and angio-oedema. Clinical and Experimental Allergy, 37, 631-650.
  • So M, et al. 2010. Safety of antihistamines during pregnancy and lactation. Canadian Family Physician, 56, 427-429.
  • Nordeng, H, et al. 2024. Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project. Basic & clinical pharmacology & toxicology, 134(1), 153–164.
  • Weber-Schoendorfer C & Schaefer C. 2008. The safety of cetirizine during pregnancy: A prospective observational cohort study. Reproductive Toxicology, 26(1), 19-23.
  • Wegler, C, et al. 2022. Simple and rapid quantification of cetirizine, venlafaxine, and O-desmethylvenlafaxine in human breast milk, and metformin in human milk and plasma with UHPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1205, 123340.
  • Wilkerson, H, et al. 2021. Maternal Transfer of Cetirizine Into Human Milk. Journal of human lactation: official journal of International Lactation Consultant Association, 37(1)135–138.
  • Wilton L, et al. 1998. The outcomes of pregnancy in women exposed to newly marketed drugs in general practice in England. British Journal of Obstetrics and Gynecology, 105, 882-889.
  • Wolfgang P, et al. 2004. Pregnancy outcome after exposure to cetirizine/levocetirizine in the first trimester–a prospective controlled study. Reproductive Toxicology 19(2):258.
  • Zyrtec Product Labeling. 09/05/2024. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b165db38-b302-4220-8627-77cb07bb078c.

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