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Codeine

Selected References

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  • Bracken MB, Holford TR. 1981. Exposure to prescribed drugs in pregnancy and association with congenital malformations. Obstet Gynecol. 58(3):336-344.
  • Brogly, SB, et al. 2021. Prenatal Opioid Analgesics and the Risk of Adverse Birth Outcomes. Epidemiology. 32(3), 448–456.
  • Broussard CS, et al. 2011. Maternal treatment with opioid analgesics and risk for birth defects. Am J Obstet Gynecol. 204(4):314.e1-11.
  • Corsi DJ, et al. 2020. Association of Maternal opioid use in pregnancy with adverse perinatal outcomes in Ontario, Canada, From 2012 to 2018. JAMA Netw Open. 3(7):e208256.
  • Corsi DJ, et al. 2021. The Effects of opioids on female fertility, pregnancy and the breastfeeding mother‐infant dyad: A Review.Clin Pharm Toxico.
  • Fältmarch S, et al. 2019. Use of opioids during pregnancy and effects of pregnancy outcomes. Pharmacoepidemiol Drug Saf. 28: 1239– 1245.
  • Fishman B, et al. 2019. Pregnancy outcome following opioid exposure: A cohort study. PLOS ONE 14(7): e0219061
  • Fronczak CM et al, 2012. The insults of illicit drug use on male fertility. Journal of andrology. 33(4): 515-528.
  • Ito S. 2018. Opioids in Breast Milk: Pharmacokinetic Principles and Clinical Implications. The Journal of Clinical Pharmacology, 58: S151-S163.
  • Juurlink DN, et al. 2012. Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study. Clinical Toxicol. 50:5.
  • Kallen B & Reis M. 2015. Use of tramadol in early pregnancy and congenital malformation risk. Reprod Toxicol. 58:246-251.
  • Kelly LE, et al. 2013. A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk. PLoS ONE. 8(7):370073.
  • Khan K & Chang J. 1997. Neonatal abstinence syndrome due to codeine. Arch Dis Child. 76:F59-F60.
  • Lind JN, et al. 2017. Maternal use of opioids during pregnancy and congenital malformations. A Systematic Review. Pediatrics. 139(6):e20164131.
  • Mangurten HH. 1980. Neonatal codeine withdrawal in infants of non-addicted mothers. Pediatrics. 65:159-160.
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  • Nezvalová-Henriksen K, et al. 2011. Effects of codeine on pregnancy outcomes from a large population-based cohort study. Eur J Clin Pharmacol. 67:1253-1261.
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  • Saxén I. 1975. Associations between oral clefts and drugs taken during pregnancy. Int J Epidemiol. 4(1):37-44.
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  • Shaw GM, et al. 1998. Maternal illness, including fever and medication use as risk factors for neural tube defects. Teratology. 57(1):1-7.
  • Semet M et al, 2017. The impact of drugs on male fertility: a review. Andrology, 5(4), 640-663.
  • Sujan AC et al, 2019. Maternal prescribed opioid analgesic use during pregnancy and associations with adverse birth outcomes: A population-based study. PLoS Medicine. 16(12).
  • S. Food and Drug Administration. 2017. Use of codeine and tramadol products in breastfeeding women – questions and answers. Available at https://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm118113.htm. Accessed November 27, 2017.
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  • Willmann, S, et al. 2009. Risk to the breast-fed neonate from codeine treatment to the mother: a
  • quantitative mechanistic modeling study. Clin. Pharmacol. Ther. 86, 634–43.
  • Yazdy MM, et al. 2013. Periconceptional use of opioids and the risk of neural tube defects. 2013. Obstet Gynecol. 122(4):838-844.
  • Zierler S, Rothman KJ. 1985. Congenital heart disease in relation to maternal use of Bendectin and other drugs in early pregnancy. N Engl J Med. 313(6):347-352.
  • Zipursky J & Juurlink DN. 2020. The Implausibility of Neonatal Opioid Toxicity from Breastfeeding. Clin Pharmacol Ther. 10.1002/cpt.1882