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Medications and More during pregnancy and breastfeeding

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Finasteride

Selected References:

  • AlSaad D, et al. 2018. Finasteride use during pregnancy and early neonatal outcome: a case report. Int J Clin Pharm 40(4): 803-805.
  • Amory JK, et al. 2007. The effect of 5- alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men. J Clin Endocrinol Metab 92:1659-1665.
  • Bowman CJ, et al. 2003. Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat. Toxicol Sci; 74:393-406.
  • Carlin JR, et al. 1992. Disposition and pharmacokinetics of (14C) finasteride after oral administration in humans. Drug Metab Dispos Biol Fate Chem; 20:148-55.
  • Cather JC, et al. 1999. Finasteride – An update and review. Cutis 64:167-172.
  • Clark RL, et al. 1990. External genital abnormalities in male rats exposed in utero to finasteride, a 5-alpha reductase inhibitor. Teratology; 42:91-100.
  • Husmann DA, McPhaul MJ. 1991. Time-specific androgen blockade with flutamide inhibits testicular descent in the rat. Endocrinology; 129:1409-1416.
  • Khera M, et al. 2020. Penile vascular abnormalities in young men with persistent side effects after finasteride use for the treatment of androgenic alopecia. Transl Androl URol 9(3): 1201-1209.
  • Kurzrock EA, et al. 2000. Urethral development in the fetal rabbit and induction of hypospadias: a model for human development. J Urol 164(5):1786-1792.
  • Laborde, E. and R. E. Brannigan. 2010. Effect of 1-mg dose of finasteride on spermatogenesis and pregnancy. J Androl 31(2): e1-2.
  • Overstreet JW, et al. 1999. Chronic treatment with finasteride daily does not affect spermatogenesis or semen production in young men. J Urol 162:1295-1300.
  • Paris JJ, et al. 2011. Inhibition of 5 alpha reductase activity in late pregnancy decreases gestational length and fecundity and impairs object memory and central progestogen milieu of juvenile rat offspring. J Neuroendocrinol. 23(11): 1079-90.
  • Prahalada S, et al. 1997. Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the Rhesus monkey (Macaca mulatta). Teratology; 55:119-31.
  • Propecia prescribing information. 2020. Accessible from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4e07adb4-7807-47d3-b9a9-2332a3047410#S12.3
  • Ricci G, et al. 2012. Finasteride and fertility: case report and review of the literature. J Drugs Dermatol; 11(12):1511-3.
  • Rittmaster, RS, 1994. Drug Therapy: Finasteride. New Engl J Med 330:120-125.
  • Salvarci A, Istanbulluoglu O. 2013. Secondary infertility due to use of low-dose finasteride. Int Urol Nephrol; 45(1):83-5.
  • Samplaski MK, et al. 2013. Finasteride use in the male infertility population: effects on semen and hormone parameters. Fertility and Sterility; 100:1528-1529.
  • Spencer JR, et al. 1991. Effects of flutamide and finasteride on rat testicular descent. Endocrinology; 129:741-748.
  • Teichert M, et al. 2017. Contraindicated use of 5-alpha-reductase inhibitors in women. Br J Clin Pharmacol. 83(2): 429-431
  • Wise LD, et al. 1991. Reversible decreases of fertility in male Sprague-Dawley rats treated orally with finasteride, a 5-alpha-reductase inhibitor. Reprod Toxicol 5:353-362.