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Folic Acid | Folate

Selected References:

  • Aslinia F, et al. 2006. Megaloblastic Anemia and Other Causes of Macrocytosis. Clinical Medicine & Research 4.3: 236-41.
  • Bortolus R., et al. 2021. Efficacy of 4.0 mg versus 0.4 mg Folic Acid Supplementation on the Reproductive Outcomes: A Randomized Controlled Trial. Nutrients, 13(12), 4422. https://doi.org/10.3390/nu13124422.
  • Centers for Disease Control and Prevention (CDC). 2022. Folic Acid Safety, Interactions, and Effects on Other Outcomes. https://www.cdc.gov/ncbddd/folicacid/faqs/faqs-safety.html [Accessed 1/2024].
  • 2017 (last reviewed 2022). Folic Acid Fortification and Supplementation. https://www.cdc.gov/ncbddd/folicacid/faqs/faqs-fortification.html [Accessed 1/2024].
  • Christian P. et al. 2010 Prenatal micronutrient supplementation and intellectual and motor function in early school-aged children in Nepal. JAMA. 304:2716–2723.
  • Crider KS, et al. 2011. Folic acid food fortification-its history, effect, concerns, and future directions. Nutrients; 3(3):370-84.
  • Cui, Y., et al. 2021. Association of maternal pre-pregnancy dietary intake with adverse maternal and neonatal outcomes: A systematic review and meta-analysis of prospective studies. Critical reviews in food science and nutrition, 1–22.
  • Dervla K, et al. 2012: Use of Folic Acid Supplements and Risk of Cleft Lip and Palate in Infants: A Population-based Cohort Study. Br J Gen Pract British Journal of General Practice 62.600: 466-72.
  • Gaskins AJ, et al. 2012. The impact of dietary folate intake on reproductive function in premenopausal women: A prospective cohort study. PLoS One 7(9): e46276.
  • Gaskins AJ, et al. 2014. Maternal prepregnancy folate intake and risk of spontaneous abortion and stillbirth. Obstet Gynecol. 124(1):23-31.
  • Gildestad T, et al. 2020. Maternal use of folic acid and multivitamin supplements and infant risk of birth defects in Norway 1999-2013. Br J Nutr. 1-38.
  • Gomez MG, et al. 2024. Global Neurosurgery at the 76th World Health Assembly (2023): First Neurosurgery-driven Resolution Calls for Micronutrient Fortification to Prevent Spina Bifida. World Neurosurg. S1878-8750(24)00101-3.
  • Hodgetts VA, Morris RK, Francis A, Gardosi J, Ismail KM. 2015. Effectiveness of folic acid supplementation in pregnancy on reducing the risk of small-for-gestational age neonates: a population study, systematic review and meta-analysis. BJOG. 122:478–490.
  • Ito K, et al. 2019. Association between maternal serum folate concentrations in the first trimester and the risk of birth defects: The Hokkaido Study of Environment and Children’s Health. J Epidemiol. 29(4):164-171.
  • Liu C, Liu C, Wang Q, Zhang Z. 2018. Supplementation of folic acid in pregnancy and the risk of preeclampsia and gestational hypertension: a meta-analysis.Arch Gynecol Obstet.; 298:697–704.
  • Liu X, et al. 2023. Folic acid supplements and perinatal mortality in China. Front Nutr. 10:1281971.
  • Li X, et al. 2023. Effects of folic acid and folic acid plus zinc supplements on the sperm characteristics and pregnancy outcomes of infertile men: A systematic review and meta-analysis. Heliyon. 13;9(7):e18224.
  • National Institutes of Health (NIH) Office of Dietary Supplements. 2022. Folate Fact Sheet for Consumers. https://ods.od.nih.gov/factsheets/Folate-Consumer/ [Accessed 1/2024].
  • NIH Office of Dietary Supplements. 2022. Folate Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/. [Accessed 1/2024].
  • Pittschieler S, et al. 2008. Spontaneous abortion and the prophylactic effect of folic acid supplementation in epileptic women undergoing antiepileptic therapy. J Neurol. 255(12):1926-31.
  • Toriello H. 2011. Policy Statement on Folic Acid and Neural Tube Defects. Genet Med 13.6: 593-96.
  • S. Food and Drug Administration (FDA). 2022. Folate and Folic Acid on the Nutrition and Supplement Facts Labels. https://www.fda.gov/food/nutrition-facts-label/folate-and-folic-acid-nutrition-and-supplement-facts-labels [Accessed 1/2024].
  • Young SS, et al. 2008. The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men. Hum. Reprod. 23 (5): 1014-1022.
  • Wang G, et al. 2016. Association between Maternal Pregnancy Body Mass Index and Plasma Folate Concentrations With Child Metabolic Health. JAMA Pediatr.
  • Wen S, et al. 2016. Folic Acid Supplementation in Pregnancy and the Risk of Pre-Eclampsia—A Cohort Study. PLoS ONE 11.2 .
  • Wong W, et al. 2002. Effects of Folic Acid and Zinc Sulfate on Male Factor Subfertility: A Double-blind, Randomized, Placebo-controlled Trial. Fertility and Sterility 77:491-8.
  • World Health Organization (WHO). 2009. Recommendations on wheat and maize flour fortification: meeting report – interim consensus statement. http://www.who.int/nutrition/publications/micronutrients/wheat_maize_fortification/en/ [Accessed 1/2024].

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