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Ibuprofen

Selected References

  • Bird TM, et al. 2009. Demographic and environmental risk factors for gastroschisis and omphalocele in the National Birth Defects Prevention Study. J Ped Surg, 44(8):1546-1551.
  • Baldacci S, et al. 2024. Medication use during pregnancy and the risk of gastroschisis: a systematic review and meta-analysis of observational studies. Orphanet J Rare Dis, 19(1):31.
  • Brandlistuen RE et al. 2013. Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled study. Int J Epidemiol, 42(6):1702-1713.
  • Choi E-Y, et al. 2023. Neonatal and maternal adverse outcomes and exposure to nonsteroidal anti-inflammatory drugs during early pregnancy in South Korea: a nationwide cohort study. PLoS Med, 20(2):e1004183.
  • Dawood MY. 1993. Nonsteroidal antiinflammatory drugs and reproduction. Am J Obstet Gynecol, 169(5):1255-1265.
  • Daniel S, et al. 2014. Fetal exposure to nonsteroidal anti-inflammatory drugs and spontaneous abortion. Can Med Assoc J 186(5):E177-E182.
  • Daniel S, et al. 2015. NSAIDs and spontaneous abortions – true effect or an indication bias? Br J Clin Pharmacol, 80(4):750-754.
  • Dathe K, et al. 2018. No evidence of adverse pregnancy outcome after exposure to ibuprofen in the first trimester—Evaluation of the national Embryotox cohort. Reproductive Toxicology, 79: 32-38.
  • Ericson A and Kallen BA. 2001. Nonsteroidal anti-inflammatory drugs in early pregnancy. Reprod Toxicol, 15:371- 375.
  • Esposito DB, et al. 2021. Periconceptional nonsteroidal anti-inflammatory drug use, folic acid intake, and the risk of spina bifida. Birth Defects Res, 113(17):1257-1266.
  • Hernandez RK, et al. 2012; Nonsteroidal anti-inflammatory drug use among women and the risk of birth defects. Am J Obstet Gynecol, 206:228.e1-e8.
  • Kavoussi PK, et al. 2018. Ibuprofen does not have an adverse impact on semen parameters. J Assist Reprod Genet 35(12):2201-2204.
  • Killick S and Elstein M. 1987. Pharmacological production of luteinized unruptured follicles by prostaglandin synthetase inhibitors. Fertil Steril, 47:773-777.
  • Kristensen DM, et al. 2018. Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism. Proc Natl Acad Sci U S A, 115(4):E715-E724.
  • Janssen NM and Genta MS. 2000. The effects of immunosuppressive and anti-inflammatory medication on fertility, pregnancy, and lactation. Arch Intern Med, 160:610-619.
  • Li DK, et al. 2003. Exposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage: population based cohort study. BMJ, 327(7411):368.
  • McInerney KA, et al. 2017. Preconception use of pain-relievers and time-to-pregnancy: a prospective cohort study. Hum Reprod, 32(1):103-111.
  • Nakhai-Pour HR et al. 2011. Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion. CMAJv 183(15):1713-1720.
  • Nezvalova-Henriksen K et al. 2013. Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective study. BJOG, 120(8):948-959.
  • Nielsen GL, et al. 2001. Risk of adverse birth outcome and miscarriage in pregnant users of non-steroidal anti-inflammatory drugs: population based observational study and case-control study. BMJ, 322(7281):266-270.
  • Nielsen GL, et al. 2004. Danish group reanalyses miscarriage in NSAID users. BMJ, 328(7431):109.
  • 2020. Can I take ibuprofen when I’m pregnant? https://www.nhs.uk/common-health-questions/pregnancy/can-i-take-ibuprofen-when-i-am-pregnant/#:~:text=It’s%20best%20to%20avoid%20taking,risk%20of%20complications%2C%20including%20miscarriage.
  • Ofori B, et al. 2006. Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: a nested case-control study. Birth Defects Res B Dev Reprod Toxicol, 77(4):268-279.
  • Penfield M, et al. 2019. Ibuprofen and postpartum blood pressure in women with hypertensive disorders of pregnancy: a randomized controlled trial. Obstet Gynecol, 134(6):1219-1226.
  • Petersen TG, et al. 2018. Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child. Int J Epidemiol, 47(1):121-130.
  • Rigourd V et al. 2014. Ibuprofen concentrations in human mature milk – first data about pharmacokinetics study in breast milk with AOR-10127 “Antalait” study. Ther Drug Monitor, 36(5):590-596.
  • Torfs CP, et al. 1996. Maternal medications and environmental exposures as risk factors for gastroschisis. Teratology, 54(2):84-92.
  • Triebwasser JE, et al. 2019. A randomized-controlled trial to assess the effect of ibuprofen on postpartum blood pressure in women with hypertensive disorders of pregnancy. Pregnancy Hypertens, 18:117-121.
  • Townsend RJ, et al. 1984. Excretion of ibuprofen into breast milk. Am J Obstet Gynecol, 149(2):184-186.
  • S. Food and Drug Administration. 2020. FDA Warns that Using a Type of Pain and Fever Medication in Second Half of Pregnancy Could Lead to Complications.Available at: https://www.fda.gov/news-events/press-announcements/fda-warns-using-type-pain-and-fever-medication-second-half-pregnancy-could-lead-complications?utm_medium=email&utm_source=govdelivery Accessed 2 Dec 2024.
  • Uhler ML, et al. 2001. The effect of nonsteroidal anti-inflammatory drugs on ovulation: a prospective, randomized clinical trial. Fertil Steril, 76(5):957-961.
  • Zafeiri A, et al. 2022. Maternal over-the-counter analgesic use during pregnancy and adverse perinatal outcomes: cohort study of 151 141 singleton pregnancies. BMJ Open, 12(5):e048092.

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