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MotherToBaby

Medications and More during pregnancy and breastfeeding

Montelukast (Singulair®)

Selected References:

  • Bakhireva LN, et al., 2007. Safety of leukotriene receptor antagonists in pregnancy. Journal of Allergy and Clinical Immunology, 119; 618-625.  
  • Cavero-Carbonell C, et al. 2017. Fetal exposure to montelukast and congenital anomalies: a population based study in Denmark. Birth Defects Res, 109(6):452-459.  
  • Datta P, et al. 2017. Transfer of montelukast into human milk during lactation. Breastfeed Med, 12:54-57. Hatakeyama S, et al., 2022. The safety of pranlukast and montelukast during the first trimester of pregnancy: a prospective, two-centered cohort study in Japan. Congenit Anom (Kyoto), 62(4):161-168. 
  • Fareed A et al. 2024. Montelukast use in pregnancy: A systematic review and meta-analysis of maternal and fetal outcomes in asthma treatment. Congenit Anom (Kyoto), 64(6):220-227. doi: 10.1111/cga.12581. Epub 2024 Aug 11. PMID: 39129058. 
  • Merck Sharp & Dohme Corp. 2022. Singulair product labeling. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm  
  • Nelsen LM, et al., 2012. Congenital malformations among infants born to women receiving montelukast, inhaled corticosteroids, and other asthma medications. J Allergy Clin Immunol, 129(1):251-254.e1-6.  
  • Sarkar M, et al. 2009. Montelukast use during pregnancy: a multicentre, prospective, comparative study of infant outcomes Eur J Clin Pharmacol, 65(12):1259-1264.  
  • The American College of Obstetricians and Gynecologists (ACOG) and The American College of Allergy, Asthma and Immunology (ACAAI). 2000. The use of newer asthma and allergy medications during pregnancy. Ann Allergy Asthma Immunol, 84:475-480. 
  • Tsai HJ et al. Use of Leukotriene-Receptor Antagonists During Pregnancy and Risk of Neuropsychiatric Events in Offspring. 2023. JAMA Netw Open, 6(3): e231934. doi: 10.1001/jamanetworkopen.2023.1934. PMID: 36881413; PMCID: PMC9993182. 

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