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Remdesivir (Veklury®)

Selected References:

  • Akinosoglou K, et al. 2023. COVID-19 Pharmacotherapy in Pregnancy: A Literature Review of Current Therapeutic Choices. Viruses. 15(3): 787.
  • Aleissa MM, et al. 2021. New perspectives on antimicrobial agents: Remdesivir treatment for COVID-19. Antimicrob Agents Chemother. 38:248-251.
  • Al-Kuraishy HM, et al. 2023. Pregnancy and COVID-19: high or low risk of vertical transmission. Clin Exp Med. 23(4):957-967.
  • Anderson J, et al. 2020. The use of convalescent plasma therapy and remdesivir in the successful management of a critically ill obstetric patient with novel coronavirus 2019 infection: A case report. Case reports in women’s health, 27, e00221.
  • Arbabzadeh T, et al. 2023. Remdesivir in pregnant women with moderate to severe coronavirus disease 2019 (COVID-19): a retrospective cohort study. Clin Exp Med. 23(7):3709-3717.
  • Budi, DS, et al. 2022. Remdesivir for pregnancy: A systematic review of antiviral therapy for COVID-19. Heliyon, 8(1), e08835.
  • Bertrand K, et al. 2024. Concentrations of remdesivir and GS-441524 in human milk from lactating individuals diagnosed with COVID-19. Pediatric research. 10.1038/s41390-024-03053-2.
  • Burwick RM, et al. 2021. Compassionate Use of Remdesivir in Pregnant Women With Severe Coronavirus Disease 2019. Clin Infect Dis. 6;73(11):e3996-e4004
  • Cheema R, et al. 2023. Protecting Breastfeeding during the COVID-19 Pandemic. Am J Perinatol. 40(3):260-266.
  • Chen M, et al. 2023. Vaccination and treatment options for SARS-CoV2 infection affecting lactation and breastfeeding. Seminars in fetal & neonatal medicine. 28(1) 101425.
  • Clinical Solutions: Remdesivir monograph. Revised 5/7/2020. https://www.elsevier.com/__data/assets/pdf_file/0008/996767/Remdesivir-Drug-Monograph_28MAY2020.pdf
  • Di Gennaro, et al. 2023. Efficacy and safety of therapies for COVID-19 in pregnancy: a systematic review and meta-analysis. BMC Infect Dis. 23(1):776.
  • Dornemann J, et al. 2017. First newborn baby to receive experimental therapies survives Ebola virus disease. J Infect Dis, 215:171–4.
  • FDA’s approval of Veklury (remdesivir) for the treatment of COVID-19—the science of safety and effectiveness. 2020. Available at: https://www.fda.gov/drugs/news-events-human-drugs/fdas-approval-veklury-remdesivir-treatment-covid-19-science-safety-and-effectiveness?msclkid=172b6876c65d11ec832b5913d0d746c5. Accessed 9 Dec 2024.
  • Frauenfelder C, et al. 2020. Infant with SARS-CoV-2 infection causing severe lung disease treated with remdesivir. Pediatrics. 146:e20201701.
  • Gilead Sciences, Inc. 2022. Remdesivir product labeling. Available at: https://www.gilead.com/-/media/files/pdfs/medicines/covid-19/veklury/veklury_pi.pdf. Accessed 9 Dec 2024.
  • Gutierrez R, et al. 2022. Remdesivir use in pregnancy during the SARS-CoV-2 pandemic, The Journal of Maternal-Fetal & Neonatal Medicine, 35(25):9445-9451.
  • Jorgensen SCJ, 2021. A review of remdesivir for COVID-19 in pregnancy and lactation. J Antimicrob Chemother. 77(1):24-30.
  • Jorgensen SC, et al. 2022. A review of COVID-19 therapeutics in pregnancy and lactation. Obstet Med. 15(4): 225-232.
  • Lampejo T. 2021. Remdesivir for the treatment of COVID‐19 in pregnancy. Journal of medical virology, 93(7), 4114.
  • Liu X, et al. 2023. Physiologically-based pharmacokinetic modeling of remdesivir and its metabolites in pregnant women with COVID-19. CPT: Pharmacometrics & systems pharmacology. 12(2) 148-153.
  • Molaei E, et al. 2024. Remdesivir: treatment of COVID-19 in special populations. Naunyn Schmiedebergs Arch Pharmacol. 397(6):3829-3855.
  • Mulangu S, et al. 2019. A randomized, controlled trial of Ebola virus disease therapeutics. N Engl J Med., 381:2293–303.
  • Naqvi M, et al. 2020.Tocilizumab and Remdesivir in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19), Obstetrics & Gynecology. 136(5):1025-1029.
  • Nasrallah, S, et al. 2021. Pharmacological treatment in pregnant women with moderate symptoms of coronavirus disease 2019 (COVID-19) pneumonia. The Journal of Maternal-Fetal & Neonatal Medicine, 1-8.
  • Pierce-Williams RAM, et al. 2020. Clinical course of severe and critical COVID-19 in hospitalized pregnancies: a US cohort study. Am J Obstet Gynecol MFM; 2(3):100134.
  • Sadati E, et al. 2022. Remdesivir in Breastfeeding. Tanaffos. 21(3) 261-262.
  • Tavakoli N, et al. 2023. Is it possible to reduce the rate of vertical transmission and improve perinatal outcomes by inclusion of remdesivir in treatment regimen of pregnant women with COVID-19?. BMC Pregnancy Childbirth. 23(1):110.
  • Wada YS, et al. 2022. Remdesivir and human milk: A case study. J Hum Lact.

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