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Sulfasalazine (Azulfidine®)

Selected References:

  • Birnie GG, et al. 1981. Incidence of sulphasalazine-induced male infertility. Gut 22:452-455.
  • Bokstrom H, et al. 2006. Fetal hemolytic anemia associated with maternal sulfasalazine therapy during pregnancy. Acta Obstet Gynecol Scand 85:118-121.
  • Connell W, Miller A. 1999. Treating inflammatory bowel disease during pregnancy: Risks and safety of drug therapy. Drug Saf 21:311-323.
  • Chatzionaff M, et al. 1988. Sulfasalazine-induced abnormal sperm penetration assay reversed on changing to 5-aminosalicylic acid enemas. Dig Dis Sci 33:108-110.
  • Hernandez-Diaz S, et al. 2000. Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med 343:1608-1614.
  • Hoo JJ, et al. 1988. Possible teratogenicity of sulfasalazine. New Engl J Med 318:112.
  • Jarnerot G, et al. 1981. Albumin reserve for binding of bilirubin in maternal and cord serum under treatment with sulphasalazine. Scand J Gastroenterol 16:1049-1055.
  • Klarsov P, et al. 2013. Short-acting sulfonamides near term and neonatal jaundice. Obstet Gynecol 122:105-110.
  • Levi AJ, Fisher AM. 1979. Male infertility due to sulphasalazine. Lancet 2:276-278.
  • Levi S, et al. 1988. Reversible congenital neutropenia associated with maternal sulphasalazine therapy (letter). Euro J Pediatr 48:174-175.
  • Mogadam M, et al. 1981. Pregnancy in inflammatory bowel disease: effect of sulfasalazine and corticosteroids on fetal outcome. Gastroenterology 80:72-76.
  • Moody GA, et al. 1997. The effects of chronic ill health and treatment with sulphasalazine on fertility amongst men and women with inflammatory bowel disease in Leicestershire. Int J Colorectal Dis 12:220-224
  • Newman NM, Correy JF. 1983. Possible teratogenicity of sulphasalazine. Med J Aust 1:528-1529.
  • Nielsen OH, et al. 1983. Pregnancy in ulcerative colitis. Scand J Gastroenterol 18(6):735-742.
  • Norgard B, et al. 2001. Population-based case control study of the safety of sulfasalazine use during pregnancy. Aliment Pharmacol Ther 15:483-486.
  • Norgard B, et al. 2003. Risk of congenital abnormalities in children born to women with ulcerative colitis: a population-based, case-control study. Am J Gastroenterol 98:2006-2010.
  • Norgard B, et al. 2007. Therapeutic drug use in women with Crohns disease and birth outcomes: a Danish nationwide cohort study. Am J Gastroenterol 102(7):1406-1413.
  • Toovey S, et al. 1981. Sulphasalazine and male infertility: Reversibility and possible mechanism. Gut 22:445-451.
  • Toth A. 1979. Male infertility due to sulphasalazine. Lancet 2:904.
  • Toth A. 1979. Reversible toxic effect of salicylazosulfapyridine on semen quality. Fertil Steril 1:538-540.
  • Viktil KK, et al. 2012. Outcomes after anti-rheumatic drug use before and during pregnancy: a cohort study among 150,000 pregnant women and expectant fathers. Scand J Rheumatol. 41(3):196-201.

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