This sheet is about exposure to prucalopride in pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare provider.
What is prucalopride?
Prucalopride is a medication used to treat adults with functional constipation, also known as chronic idiopathic constipation. Here, chronic means that symptoms, such as hard, infrequent bowel movements, have been happening for at least 6 months. Idiopathic means that the cause is not known. Prucalopride is sold under the brand name Motegrity®.
Other forms of constipation might respond to over-the-counter (OTC) laxatives. For more information about OTC laxatives, please see the general laxatives MotherToBaby fact sheet at https://mothertobaby.org/fact-sheets/laxatives/.
Sometimes when women find out they are pregnant, they think about changing how they take their medication or stopping their medication altogether. However, it is important to talk with your healthcare providers before making any changes to how you take this medication. Your healthcare providers can talk with you about the benefits of treating your condition and the risks of untreated illness during pregnancy.
I take prucalopride. Can it make it harder for me to get pregnant?
Studies have not been done to see if prucalopride could make it harder to get pregnant.
Does taking prucalopride increase the chance for miscarriage?
Miscarriage is common and can occur in any pregnancy for many different reasons. It is not known if prucalopride increases the chance of miscarriage,
Does taking prucalopride increase the chance of birth defects?
Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. It is not known if prucalopride increases the chance for birth defects above the background risk. Human studies have not been done to see if prucalopride increases the chance for birth defects. Animal studies done by the manufacturer did not show an increase in birth defects with exposure to prucalopride.
Does taking prucalopride in pregnancy increase the chance of other pregnancy-related problems?
Studies have not been done to see if prucalopride increases the chance for pregnancy-related problems such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth).
Does taking prucalopride in pregnancy affect future behavior or learning for the child?
Studies have not been done to see if prucalopride can cause behavior or learning issues for the child.
Breastfeeding while taking prucalopride:
There are no published studies looking at the use of prucalopride during breastfeeding. The manufacturer reports an unpublished study that indicates a relatively low amount of prucalopride is passed into breast milk. If you suspect the baby has any symptoms (such as diarrhea), contact the child’s healthcare provider. Be sure to talk to your healthcare provider about all of your breastfeeding questions.
If a man takes prucalopride, could it affect fertility (ability to get a woman pregnant) or increase the chance of birth defects?
Studies have not been done to see if prucalopride could affect a man’s fertility or increase the chance of birth defects. In general, exposures that men have are unlikely to increase the risks to a pregnancy. For more information, please see the MotherToBaby fact sheet Paternal Exposures at https://mothertobaby.org/fact-sheets/paternal-exposures-pregnancy/
MotherToBaby is currently conducting a study looking at functional constipation and the medications used to treat it in pregnancy. If you are interested in learning more about this study, please call 1-877-311-8972 or visit https://mothertobaby.org/join-study.
Please click here to view references.
