This sheet talks about exposure to sumatriptan in pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare provider.

What is sumatriptan?

Sumatriptan (Imitrex®, Imigran®) is a medication used to treat migraine headaches. It can be used orally (pill), by nasal spray or by injection (shot). Sumatriptan is also available in a combination product (Treximet®) that also contains naproxen. Naproxen containing products are best to avoid during late pregnancy. For more information on naproxen, see our fact sheet at

Are there any effects of having a migraine headache during pregnancy?

During pregnancy, the frequency and severity of migraines often decreases, although in 25% of women these symptoms remain the same or get worse. Some studies have shown that women with a history of migraine headaches have a slightly higher chance for pregnancy complications including high blood pressure, preeclampsia (dangerously high blood pressure) and pregnancy-related stroke.

I take sumatriptan. Can it make it harder for me to get pregnant?

Studies have not been done to see if sumatriptan could make it harder for a woman to get pregnant.

I just found out I am pregnant. Should I stop taking sumatriptan?

Talk with your healthcare providers before making any changes to this medication.

Does taking sumatriptan during my pregnancy increase the chance of miscarriage?

Miscarriage can occur in any pregnancy. Several studies have not found an increase in the rate of miscarriage when sumatriptan was used during pregnancy.*

Does taking sumatriptan increase the chance of having a baby with a birth defect?

In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This is called her background risk. Overall, the studies have not found an increase in the chance of birth defects when sumatriptan is used in the first trimester.*

Can taking sumatriptan in the second or third trimester cause other pregnancy complications?
Concerns have been raised about whether the use of sumatriptan late in pregnancy may be associated with preeclampsia (dangerously high blood pressure), preterm birth, low birth weight and heavy bleeding following delivery. Several studies have noticed a small increased chance for these outcomes. However, it is not yet clear if these outcomes were due to the migraines or the medications or a combination of both.

Can I breastfeed my baby if I am taking sumatriptan?

Only small amounts of sumatriptan enter breastmilk. Since sumatriptan is not well absorbed by the gut, any of the medication that gets into breast milk would be unlikely to enter the baby’s system making it unlikely to cause problems for the baby. It is possible that premature babies (born before 37 weeks) with digestive systems that are not fully developed may be able to absorb more of the medication through breast milk. Be sure to talk to your health care provider about all your breastfeeding questions.*

What if the baby’s father takes sumatriptan?

There are no studies looking at possible risks to a pregnancy when a father has migraine headaches or uses sumatriptan. In general, exposures that fathers have are unlikely to increase risks to a pregnancy. For more information, please see the MotherToBaby fact sheet Paternal Exposures at*

* Section Updated May 2020

Selected References

  • Selected References
  • Amundsen S, et al. 2015. Pharmacological treatment of migraine during pregnancy and breastfeeding; Nat. Reviews Neurol; 11(4): 209-215.
  • Bánhidy F, et al. 2006. Maternal severe migraine and risk of congenital limb deficiencies. Birth Defects Res a Clin Mol Teratol; 76(8):592-601.
  • Cunnington M, et al. 2009. The safety of sumatriptan and naratriptan in pregnancy: what have we learned? Headache; 49(10):1414-22.
  • David PS, et al. 2014. Migraine in pregnancy and lactation. Curr Neurol Neurosci Rep; 14(4):439.
  • Duong S, et al. 2010. Safety of triptans for migraine headaches during pregnancy and breastfeeding. Can Fam Physician; 56(6):537-9.
  • Ephross AS, et al. 2014. Final results from the 16 year sumatriptan, naratriptan, and treximet pregnancy registry. Headache; 54(3):1158-1172.
  • Jarvis S, et al. 2018. Managing migraine in pregnancy. BMJ 360:k80.
  • Källén B, et al. 2011. Delivery outcome after maternal use of drugs for migraine: a register study in Sweden. Drug Saf; 34(8):691-703.
  • MacGregor AE, et al. 2014. Migraine in pregnancy and lactation. Neurol Sci; 35(Suppl 1): S61-S64.
  • Negro A, et al. 2017. Headache and pregnancy: a systematic review. The Journal of Headache and Pain; 18(1):106.
  • Nezvalová-Henriksen K, et al. 2010. Triptan exposure during pregnancy and the risk of major congenital malformations and adverse pregnancy outcomes: results from the Norwegian Mother and Child Cohort Study. Headache; 50(4):563-75.
  • Nezvalová-Henriksen K, et al. 2013. Triptan safety during pregnancy: a Norwegian population registry study. Eur J Epidemiol; 28(9):759-69.
  • Olesen C, et al. 2000. Pregnancy outcome following prescription for sumatriptan. Headache; 40(1):20-4.
  • Spielmann K, et al. 2018. Pregnancy outcome after anti-migraine triptan use: a prospective observational cohort; Cephalagia 38(6):1081-1092.
  • Wabnitz A, Bushnell C. 2015. Migraine, cardiovascular disease, and stroke during pregnancy: systematic review of the literature. Cephalalgia; 35(2):132-9.
  • Wojnar-Horton RE, et al. 1996. Distribution and excretion of sumatriptan in human milk. Br J Clin Pharmacol; 41(3):217-21.